Cognition Clinical Trial
Official title:
Effect of Fingolimod on Neurodegeneration, Brain Atrophy and Cognitive Impairment in Relapsing Remitting Multiple Sclerosis Patients
This was a 24-month, open-label, multicenter study with a single treatment arm design.
Primary objective of this study was:
-To investigate the effects of Fingolimod on cognitive performance in highly active relapsing
remitting multiple sclerosis patients
Secondary objectives of this study were:
- To investigate the correlation between the effect of fingolimod on cognitive
performances and MRI data.
- To evaluate the effect of fingolimod on biomarkers (24 hydroxy cholesterol, osteopontin
and matrix metalloproteinases) related to neurodegeneration
- To investigate the effect of fingolimod on brain gray matter atrophy and thalamic
atrophy.
Polulation The hope was to recruit a minimum of 80 relapsing remitting MS (RRMS) patients
according to the McDonald criteria.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT04540523 -
Home-Based Exergaming Intervention
|
N/A | |
| Suspended |
NCT01212029 -
Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging
|
N/A | |
| Enrolling by invitation |
NCT05273970 -
Electrochemical and Electrophysiological Study
|
N/A | |
| Recruiting |
NCT05227352 -
Bio-Experiential Spaces for Mental Health in Healthworkers
|
N/A | |
| Completed |
NCT02671149 -
The Effect of Small Changes in Hydration on Cognition
|
N/A | |
| Completed |
NCT01333306 -
Enhancing Cognitive Training Using tDCS
|
Phase 1 | |
| Recruiting |
NCT05542199 -
Nutrition for Brain and Body Health (BB-Health) Feasibility Trial
|
N/A | |
| Recruiting |
NCT06254638 -
Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)
|
N/A | |
| Recruiting |
NCT06331286 -
The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity
|
N/A | |
| Completed |
NCT05998096 -
A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, Reaction Time, and Other Perceptual Indicators
|
N/A | |
| Withdrawn |
NCT03224559 -
Applying Neuromodulation to Accelerate Training Effects
|
||
| Completed |
NCT03129048 -
Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults
|
N/A | |
| Recruiting |
NCT05394363 -
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
|
||
| Suspended |
NCT05107947 -
Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm
|
N/A | |
| Recruiting |
NCT05372172 -
Tennessee Alzheimer's Project
|
||
| Recruiting |
NCT05132517 -
Magnesium and Cognition After Stroke
|
||
| Recruiting |
NCT05992571 -
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
|
N/A | |
| Recruiting |
NCT06097182 -
Postbiotic Intervention for Acute Stress Management
|
N/A | |
| Completed |
NCT01223404 -
Nicotinic Modulation of the Default Network
|
N/A | |
| Completed |
NCT00687102 -
Cognition in the Study of Tamoxifen and Raloxifene
|
Phase 3 |