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Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity

Cognition Clinical Trial

Official title:
The Impact of Acute Oral Ketone Monoester Supplementation on Resting-state Brain Connectivity in Adults With Memory Complaints

Clinical Trial Summary

People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow. Interventions that can restore cerebral metabolism and enhance cerebral blood flow may protect against conversion to dementia. Exogenous ketone supplements have been shown rapidly improves brain network function in young adults. Further, infusion studies demonstrate that ketone bodies enhance cerebral blood flow in cognitively normal adults. Whether acute ketone monoester supplementation can improve brain function in adults with subjective memory complaints is currently unknown. This study will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05992571
Study type Interventional
Source McMaster University
Contact Jeremy Walsh, PhD
Phone 905-525-9140
Email walshj18@mcmaster.ca
Status Recruiting
Phase N/A
Start date October 25, 2023
Completion date August 2024
View Details
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