Aging Clinical Trial
Official title:
Bioavailability and Impact of the Administration of Coenzyme Q10, on Mitochondrial Function Associated With Exercise Under Stress Conditions in Physically Active Individuals of Senescence Age
It is proposed to establish a group of subjects composed of 10 healthy individuals of> 50 years and <65, physically active, without metabolic or inflammatory pathology. All of them will undergo a health examination and the physical condition and the absence of contraindication of the sports practice will be characterized through a monitored effort test. Each subject will take a capsule of coenzyme Q10® INDENA for 30 days. The dose to be administered is 100 mg/d of CoQ10 a with food (noon). The state of physical condition and the biochemical and biological variables that reflect oxidative stress and mitochondrial functioning before and after the intervention will be measured.
The purpose of the study is in the first time determine the variation of the levels of
coenzyme Q10 in different tissues, plasma, urinary epithelium, muscle, mononuclear cells,
before and after the administration during one month of 100 mg of phytosomal ubiquinone
(INDENA). Secondly, it is intended to determine the antioxidant functionality of the
administered ubiquinone, evaluating its effect on the oxidative pattern that occurs after an
exercise of moderate intensity, but performed in a stressful environment, a climatic chamber
where the temperature is 35ºC and there is 55% humidity. To this end, the collaboration of 12
healthy volunteers, and 10 control subjects, over 50 and under 65, active runners with
experience, without active inflammatory pathology, without prescribed medical treatment and
with the commitment not to take any nutritional supplementation. There is also a compromise
by athletes on maintaining the diet and training as it is at the time of the first evaluation
The subjects sign an informed consent to carry out the study and they are shown the
acceptance of the Ethics Committee approved by the General Directorate of Sports of the
Generalitat of Catalonia. Basal blood samples are taken, the sample is taken from the first
urine in the morning and a muscle biopsy is performed on the vastus lateralis of the m.
quadricipitalis. On a second day, a progressive, maximum effort test is carried out in order
to characterize the level of physical condition and determine the working regimes in the
climatic chamber. They are re-scheduled for a third day for that purpose. On that day blood
is drawn to obtain the Total Antioxidant Capacity of the blood and they are exposed to the
temperature and humidity and are asked to run on the treadmill for 5 minutes at each of the
speeds corresponding to 70, 75 and 80% of the maximum speed reached in the first test. At the
end a lactate sample is taken. This period of 15 minutes is repeated 3 times. When finished,
at the 30th minute, a new blood sample is taken to assess the TAC postexercise/exposition.
The stress test and blood extractions, urine collection and muscle biopsy are repeated after
one month of taking the phytosomed Ubiquinone.
There is a control group of 10 subjects who follow absolutely the same path, but do not take
any supplementation (Ubiquinone) and do not have a muscle biopsy.
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