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Coagulation Disorder clinical trials

View clinical trials related to Coagulation Disorder.

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NCT ID: NCT05162339 Completed - Clinical trials for Inflammatory Bowel Diseases

Inflammatory Bowel Disease and Thromboembolic Events

Start date: November 1, 2016
Phase:
Study type: Observational [Patient Registry]

The main objective was to demonstrate the existence and importance of hypercoagulability in patients with IBD, by determining the prevalence of changes in coagulation parameters and evaluating the impact of these changes on the occurrence of thromboembolic events.

NCT ID: NCT05156983 Recruiting - Clinical trials for Coagulation Disorder

A Study of TAK-330 for Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation

Start date: August 24, 2022
Phase: Phase 3
Study type: Interventional

The aim of this study is to find out the effects of TAK-330 compared with four-factor prothrombin complex concentrate (4F-PCC) as part of standard treatment other than Prothromplex Total for anticoagulation reversal in participants treated with Factor Xa inhibitors who require urgent surgery/invasive procedure. The participant will be assigned by chance to either TAK-330 or SOC 4F-PCC as part of standard treatment before surgery. Patients participating in this study will need to be hospitalized. They will also be contacted (via telehealth/phone call) 30 days after the surgery.

NCT ID: NCT05152420 Completed - Clinical trials for Coagulation Disorder

Study of Intravenous VMX-C001 in Healthy Subjects and in Combination With Selected Direct Oral Anticoagulants in Healthy Older Subjects

Start date: October 29, 2021
Phase: Phase 1
Study type: Interventional

A single centre, double-blind, randomized, parallel group, placebo-controlled study in healthy subjects conducted in two parts: Part 1: Single ascending doses in healthy subjects aged 18 to 49 years to assess safety, pharmacokinetics (PK) and pharmacodynamic (PD) effects of VMX-C001. Part 2: Healthy subjects aged 50 to 79 years to assess safety, PK and PD effects of VMX-C001 in the presence of DOACs.

NCT ID: NCT05139589 Recruiting - Clinical trials for Coagulation Disorder

The ENDOCARDITIS AUMC Data Collection

ENDO_AUMC
Start date: August 6, 2023
Phase:
Study type: Observational [Patient Registry]

The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.

NCT ID: NCT05137249 Completed - COVID-19 Clinical Trials

The Glycocalyx in COVID-19 Patients. A Pilot Study

Glycovid-19
Start date: December 1, 2020
Phase:
Study type: Observational

The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS. We aim to generate first hints regarding the impact of covid-19 disease on the (damage) of the endothelial glycocalyx. Furthermore, we want to investigate the potential coagulopathies, which go along with shedding of the glycocalyx. The detection of and the relation between the severity of the disease, as well as the extent of the glycocalyx damage during the observational period, as well as the hemostatic alterations, are aim of the study.

NCT ID: NCT05006378 Completed - Clinical trials for Coagulation Disorder

Effect of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers

Start date: August 31, 2021
Phase: N/A
Study type: Interventional

Chamomile may possess anticoagulant effects based on the presence of coumarin-like compounds within the flower. This randomized, placebo-controlled complete crossover study will investigate the impact of chamomile ingestion on coagulation.

NCT ID: NCT04777097 Recruiting - Blood Loss Clinical Trials

Blood Loss and Preeclampsia

Start date: January 1, 2021
Phase:
Study type: Observational

Study of blood loss in preeclamptic patients using mathematical formulae

NCT ID: NCT04762576 Recruiting - Clinical trials for Coagulation Disorder

Thrombin in Cardiac Surgery

Start date: August 10, 2022
Phase:
Study type: Observational

Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical patients. The investigators will measure thrombin generation using our novel device and compare it to standard methods, while examining the association of thrombin parameters with bleeding and other clinical outcomes.

NCT ID: NCT04697498 Recruiting - Chronic Pain Clinical Trials

Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations

BBESPB
Start date: December 16, 2020
Phase: N/A
Study type: Interventional

Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain. Development and implementation in clinical practice perioperative intensive care protocols for surgical correction of spinal deformities.

NCT ID: NCT04524637 Recruiting - Clinical trials for Traumatic Brain Injury

The Utility of Thromboelastography in Traumatic Brain Injury

Start date: September 1, 2018
Phase:
Study type: Observational

Hemocoagulation disorder is recognized to have crucial effects on hemorrhagic or ischemic diseases. Coagulation-related damages secondary to traumatic brain injury are common and severe secondary insults of head trauma and often leads to a poor prognosis. In this study, we sought to assess if posttraumatic hemocoagulation disorders determined using thromboelastography are associated with coagulation-related damages secondary to traumatic brain injury, and evaluate their influence on outcome among patients with head trauma. Based on above results, prediction models or risk scoring systems will be further developed and validated to predict coagulation-related damages secondary to traumatic brain injury.