Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate

Clomiphene Citrate Resistant Polycystic Ovary Syndrome Clinical Trial

Official title: Evaluation of the Clinical Outcome of Vitamin E as Adjuvant Therapy in Patients With Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Status Completed

Clinical Trial Summary

This study evaluate the addition of Vit E to clomiphene citrate in the treatment of poly cystic ovary.Half the patients will receive both Vit E and clomiphene citrate the other half will receive clomiphene citrate only.

Clinical Trial Description

Clomiphene and vit E each used in treatment of pco but they do so by different mechanisms.

Clomifene is in the selective estrogen receptor modulator (SERM) family of medication. It works by causing the release of gonadotropin-releasing hormone by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.

Vit E is used in treatment of pco due its anti-oxidant effect. ;

Related Conditions & MeSH terms

• Clomiphene Citrate Resistant Polycystic Ovary Syndrome
• Polycystic Ovary Syndrome
• Syndrome

• NCT number: NCT03674385
• Study type: Interventional
• Source: Ain Shams University
• Status: Completed
• Phase: Phase 2
• Start date: July 19, 2018
• Completion date: March 30, 2019