Cirrhosis Clinical Trial
Official title:
Evaluation of the Role of Plasma Biomarkers for Portal Hypertension Progression and Oxidative Damage in Decompensation of Cirrhotic Patient.
This is a single-center and prospective study to identify specific biomarker in order to
predict development of decompensation in cirrhotic patients.
The duration of the study is 36 months and it provides a cohort of 200 patients.
At screening, patient will have taken blood samples and performed hepatic vein pressure
gradient.
After randomization, patient will be seen at follow up every 3 months to do blood sample and
every 12 months to undergo hepatic vein pressure gradient , according to the guidelines.
In addition, metabolomics analysis will be performed at screening and every 3 months. The
results will be analyzed in relation to emergence of decompensation during follow up period,
in order to identify specific metabolomics characteristics that may be able to predict
decompensation.
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