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Circadian Dysrhythmia clinical trials

View clinical trials related to Circadian Dysrhythmia.

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NCT ID: NCT06411561 Not yet recruiting - Dementia Clinical Trials

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

SLEEP-COG
Start date: July 1, 2024
Phase: N/A
Study type: Interventional

Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both sleep deficiency and profound inactivity. About 75-80% of ICU patients experience circadian dysrhythmia, which contributes to cognitive decline and increases likelihood of developing Alzheimer's disease and related dementias. The scientific premises of the proposed study are: 1) a combined sleep promotion and cognitive training intervention will have synergistic effects to mitigate the risk of cognitive impairment and development of Alzheimer's disease and related dementias in older ICU survivors; and 2) chronotherapeutic timing of interventions (i.e., adjusting timing of interventions according to circadian rhythm) may improve intervention efficacy.

NCT ID: NCT05807178 Not yet recruiting - Clinical trials for Circadian Dysrhythmia

Enhancement of Circadian Rhythms in ICU Patients Through Light Intervention

Start date: December 1, 2024
Phase: N/A
Study type: Interventional

The investigators will examine the effects of dynamic light therapy on circadian rhythms in intensive care unit (ICU) patients. In a randomized controlled trial (RCT), they will investigate the effects of a specific light algorithm on rhythms of serum melatonin, clock gene expression, the proteome, and metabolome, compared to standard hospital lighting, supported by the data science algorithms to improve vital-based algorithms with light interventions.

NCT ID: NCT05683483 Recruiting - Surgery Clinical Trials

WEsleep Trial: Improving Sleep in Hospitalized Patients

WEsleep
Start date: April 11, 2023
Phase: N/A
Study type: Interventional

In the WEsleep study, the investigators will perform a cluster randomized controlled trial. 3 surgical and 3 medical departments will be randomized to implement low-cost and simple interventions aimed at improving sleep in admitted patients. Another 3 surgical and 3 medical departments will be randomized to function as control groups. Subjective sleep quality and sleep-wake timing will be assessed in adult medical and surgical patients admitted into one of 12 participating wards, using questionnaires and a sleep diary. In addition, in a subset of participants, objective sleep measures will be assessed in with an EEG headband and a sleep mat.

NCT ID: NCT05467410 Recruiting - Aging Clinical Trials

Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors

OPTIMIZE
Start date: November 15, 2023
Phase: N/A
Study type: Interventional

More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment. After ICU discharge, ICU survivors often experience sleep disturbances and inactivity, and almost 80% of ICU patients experience disturbances in circadian rhythm, which may affect cognitive function. Understanding the optimal, chronotherapeutic timing of cognitive interventions is crucial to promote circadian realignment and cognitive function, and may improve intervention feasibility, acceptability, and efficacy. Specific Aim 1 will determine feasibility, acceptability, and preliminary effect sizes for: 1) a morning session of a computerized cognitive training intervention [COG]; and 2) a late afternoon/early evening session of the COG intervention; compared to 3) standard inpatient care/usual care [UC]. Specific Aim 2 will examine circadian rhythm parameters to determine the optimal timing of the daily COG intervention. Exploratory Aim 3 will explore if the effects of the COG intervention on cognitive function are mediated by daytime activity, and explore if selected biological and clinical factors moderate intervention effects on cognitive function.

NCT ID: NCT05347784 Completed - Clinical trials for Postoperative Complications

Vital Values at Circadian Markers in Postoperative Patients

Start date: February 20, 2018
Phase:
Study type: Observational

To describe changes in various diurnal patterns in vital values after surgery. These will be analyzed based on whether the patients have complications or no complications.

NCT ID: NCT04953767 Recruiting - Delirium Clinical Trials

The Circadian Rhythm of ICU Patients With Acute Myocardial Infraction and the Effect of Light Therapy

Start date: May 12, 2021
Phase: N/A
Study type: Interventional

By using subjective and objective measurements, the investigators monitor the change of circadian rhythm in Intensive Care Unit (ICU) patients with acute myocardial infarction and the effect of light therapy.

NCT ID: NCT03478306 Completed - Clinical trials for Diabetic Retinopathy

Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm

Start date: March 27, 2018
Phase: Phase 3
Study type: Interventional

This study evaluates the effect of melatonin 4 mg on circadian rhythm and visual function of patients with diabetes mellitus. Half of the patients will receive melatonin (arm-1) and the other half will receive placebo (arm-2), both groups in 3 weeks. After a week of washout, the patients will cross over to the other treatment arm.

NCT ID: NCT03217708 Withdrawn - Clinical trials for Circadian Dysrhythmia

Post Discharge Circadian Rhythms Post Adenotonsillectomy

Start date: August 21, 2017
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to utilize non-invasive, easily measurable biomarkers (heart rate, skin temperature, sleep, and activity) in the post surgical discharge period to identify trends which correlate with improved outcome and early recovery (return to baseline activity). These are measured (captured) utilizing a wearable technology (WT) device. Return to baseline (RTB) activity for the purpose of this study is defined primarily as step count normalization as a surrogate of activity (pre versus post operative step count), and heart rate variability normalization back to preoperative baseline. Increased heart rate variability has been studied in acute care settings as a marker of poor prognosis. Please note that return to baseline is not defined for the pediatric population in the same way as adults (which is primarily questionnaire based and not applicable in children).