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NCT00664222 Clinical Trial

Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

Chronic Stable Heart Failure Clinical Trial

Official title:
Effects of Spironolactone on Insulin Resistance in Patients With Chronic Heart Failure

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00664222
Other study ID # #344.1
Secondary ID
Status Completed
Phase Phase 4
First received April 18, 2008
Last updated April 21, 2008
Start date January 2004
Est. completion date December 2005

Study information
Verified date April 2008
Source Tottori University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Description:

Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Recruitment information / eligibility
Status Completed
Enrollment 16
Est. completion date December 2005
Est. primary completion date
Accepts healthy volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- chronic stable heart failure

Exclusion Criteria:

- renal dysfunction or under treatment with antidiabetic agents

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• spironolactone + furosemide
spironolactone 25mg/day, 16 weeks and furosemide 20mg/day, 16weeks

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Tottori University Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary insulin resistance 16 weeks
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