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CST1-Guided Oral Glucocorticoids Management for CRSwNP — COMPASS  

Chronic Rhinosinusitis With Nasal Polyps Clinical Trial

Official title:
Efficacy of CST1-Guided Oral Glucocorticoid Therapy for Chronic Rhinosinusitis With Polyps

Clinical Trial Summary

Topical and systemic steroids constitute the first choice in medical treatment for nasal polyps. Glucocorticoids sensitivity is significantly correlated with CST1 in nasal secretions. The goal of this randomized, double-blind, placebo-controlled clinical trial is to clarify the efficacy of a short course of CST1-guided oral glucocorticoids therapy for chronic rhinosinusitis with nasal polyps. Subjects were randomized to receive either oral glucocorticoids or oral placebo for 2 weeks. Endoscopic polyp score, Total Nasal Symptom Score(TNSS), SNOT-22 score, Cystatin 1 and other biomarkers were evaluated before and after the treatment. Researchers will compare oral glucocorticoids group and oral placebo group to test CST1 predictive model of glucocorticoid therapy for Chronic Rhinosinusitis with Polyps.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05598411
Study type Interventional
Source Beijing Tongren Hospital
Contact Lou Zhang
Phone +86-13910830399
Email dr.luozhang@139.com
Status Not yet recruiting
Phase Phase 4
Start date October 17, 2022
Completion date November 1, 2025
View Details
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