Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation — NeuroPRF  

Neuropathic Pain Clinical Trial

Official title: Efficacy of Platelet Rich Fibrin in the Prevention of Residual Neuropathic Pain Following Disc Herniation Surgery

Status Recruiting

Clinical Trial Summary

The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of new techniques to prevent this chronic pain. Certain well-tolerated techniques, such as the administration of plasma enriched with platelets and fibrin (PRF), are increasingly used in regenerative medicine for their anti-inflammatory and analgesic properties. Thus, a periradicular intraoperative application of PRF may have an analgesic effect on the intensity of residual postsurgical neuropathic pain after disc herniation surgery.

Clinical Trial Description

A superiority study, phase III, prospective, single-center, randomized in parallel groups and conducted in a single-blind manner, with evaluation by a blind outcome assessor. Patients will be randomized to one of two treatment groups: Experimental group (surgery and periradicular administration of PRF) or Control group (reference treatment, surgery alone). ;

Related Conditions & MeSH terms

• Chronic Postsurgical Pain
• Hernia
• Intervertebral Disc Displacement
• Neuralgia
• Neuropathic Pain
• Pain, Postoperative

• NCT number: NCT05196503
• Study type: Interventional
• Source: University Hospital, Strasbourg, France
• Contact: Erci SALVAT
• Phone: +33 3 88 12 85 02
• Email: eric.salvat@chru-strasbourg.fr
• Status: Recruiting
• Phase: Phase 3
• Start date: February 23, 2022
• Completion date: January 2025