Clinical Trials Logo

Clinical Trial Summary

Breast cancer is considered the commonest malignancy affecting women with an incidence exceeding one million cases per year. Although it has a favorable prognosis with improved lines of treatment, some complications may still disturb the patient's life quality. One of these complications is post-mastectomy pain syndrome (PMPS) .Regional Anaesthesia (RA) is considered one of the most effective methods in reducing acute pain after breast surgeries, these include pectoral nerves block (PECS), serratus anterior plane block (SAPB), paravertebral plane block (PVPB) and erector spinae plane block (ESPB) . Our study is aiming for comparing the effect of preoperative PVPB versus preoperative ESPB in the prevention of PMPS in patients undergoing unilateral breast surgeries.


Clinical Trial Description

Breast cancer is considered the commonest malignancy affecting women with an incidence exceeding one million cases per year. Although it has a favorable prognosis with improved lines of treatment, some complications may still disturb the patient's life quality. One of these complications is post-mastectomy pain syndrome (PMPS) ¹. The International Association for Study of Pain (IASP) defines PMPS as chronic pain that persists more than 3 months in the anterior thorax, axilla &/or upper arm ². It is usually neuropathic in nature includes altered sensations such as dysesthesia, hypo or hyperesthesia, allodynia or particular qualities of dysesthesia e.g burning, dull aching sensations. It is usually of at least moderate intensity and may be either continuous or intermittent pain ³. The etiology and mechanism of PMPS remain incompletely clear yet. Some risk factors are believed to be associated with PMPS, including the presence and intensity of postoperative pain, the type of surgery, younger women, prior history of other types of pain and adjuvant therapies like chemo or radiotherapy ⁴. Regional Anaesthesia (RA) is considered one of the most effective methods in reducing acute pain after breast surgeries, these include pectoral nerves block (PECS), serratus anterior plane block (SAPB), paravertebral plane block (PVPB) and erector spinae plane block (ESPB) ⁵. Theoretically RA can minimize the development of PMPS by decreasing the afferent nociceptive input and central sensitization during the perioperative period, However clinically the role of RA in preventing PMPS is still under investigations ⁶. PVPB includes injecting local anesthetic in the paravertebral space where the spinal nerves exit from the intervertebral foraminae. Paravertebral space is bounded by the parietal pleura, superior costotransverse ligament, vertebrae, intervertebral foraminae and the heads of the ribs ⁷. While ESPB includes injection of the local anesthetic in the fascial plane between the vertebral transverse processes and the erector spinae muscle ⁸. Many studies were done in order to evaluate the efficacy of either ESPB or PVB in controlling acute postoperative pain after breast surgeries, some studies compared between them in controlling acute postoperative pain after breast surgeries ⁹. Also there are some studies that evaluate the effect of either ESPB or PVPB in the prevention of PMPS after breast surgeries ¹⁰, but still the comparison between the effect of preoperative ESPB versus the effect of preoperative PVPB in the prevention of PMPS in patients undergoing breast surgeries is still under investigated. Our study is aiming for comparing the effect of preoperative PVPB versus preoperative ESPB in the prevention of PMPS in patients undergoing unilateral breast surgeries. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06036979
Study type Interventional
Source National Cancer Institute, Egypt
Contact Suzan Ahmed, MS degree in Anaesthesia
Phone 00201004610287
Email suzansayed@yahoo.com
Status Recruiting
Phase N/A
Start date November 1, 2023
Completion date December 1, 2024

See also
  Status Clinical Trial Phase
Completed NCT02190682 - Data Collection for Prediction of Postoperative Chronic Pain for a Software
Completed NCT02630849 - Does a Multimodal no‐Compression Suture Technique of the Intercostal Space Reduce Chronic Post‐Thoracotomy Pain? N/A
Recruiting NCT05062356 - Pain Control Following Total Hip Arthroplasty Phase 1
Completed NCT03529201 - QLB After Nephrectomy N/A
Active, not recruiting NCT02924519 - Postoperative Pain After Ambulatory Arthroscopic Shoulder Surgery N/A
Completed NCT01388946 - Analgesia in Laparoscopic Cholecystectomy N/A
Completed NCT04280432 - Monocentric Observational Study: Postoperative Pain After Cesarean Section: Incidence and Risk Factors.
Enrolling by invitation NCT04508465 - Persistent Postoperative Pain After Major Emergency Abdominal Surgery
Withdrawn NCT04670042 - Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery N/A
Recruiting NCT06281431 - A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain N/A
Completed NCT01467102 - euCPSP: European Observational Study on Chronic Post Surgical Pain,PAIN-OUT Study N/A
Recruiting NCT05920967 - PANDORA: Paravertebral AdjuNctive DexamethasOne Palmitate Reducing Chronic Pain After Caridiac Surgery N/A
Completed NCT01510496 - Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy: Analysis of Risk Factors and Association With Genetic Polymorphisms N/A
Not yet recruiting NCT03363672 - Prevalence, Impact and Predictors of Chronic Postoperative Pain N/A
Not yet recruiting NCT03275207 - Dexmedetomidine for Prevention of Chronic Postoperative Pain Phase 4
Not yet recruiting NCT02991287 - Validation of Predictive Scale of Chronic Postsurgical Pain N/A
Completed NCT02115945 - Femoral and Epidural Block After Total Knee Arthroplasty Phase 0
Completed NCT04313855 - Help With Early Detection of Postoperative Neuropathic Pain Using SMS After Ambulatory Surgery N/A
Active, not recruiting NCT04604847 - Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics N/A
Enrolling by invitation NCT04735211 - Chronic Postsurgical Pediatric Pain. Evaluation Risk Factors to Develop Chronic Postsurgical Pain in Children and Adolescents Undergoing Surgery in a First Level Hospital