Chronic Postoperative Pain Clinical Trial
Official title:
Evaluation of the Prevalence and Impact of Chronic Postoperative Pain and Risk Factor Analysis: a Multi-center Prospective Cohort Study
Chronic postoperative pain (CPP) remains a disturbing and obscure clinical problem, which could last for more than 3 months after surgery. The aim of present study was to assess the prevalence of CPP, investigate its impact on life quality and explore its potential risk factors. After informed consent was signed, patients receiving surgery under general anesthesia in Peking Union Medical College Hospital and other medical centers participating in this study during 2018 will be included. Patients' preoperative information will be collected from medical record, including basic demographic data, primary disease and previous chronic diseases. Intraoperative information will be obtained from anesthesia record, including surgical scope, duration, length and location of incisions and blood loss. Acute pain will be evaluated in the ward of the department of surgery, when an app will be installed on patients' mobile phones. Our long-term postoperative follow-up would be performed by sending out survey questionnaires via this app in the 4th, 8th, 16th, 32th, and 48th weeks after surgery. The survey covers questions regarding the intensity, characteristic, location and impact on daily activities of CPP. Information regarding treatment of CPP will also be collected, if any. All the data gained will be summarized in our database and analyzed.
Chronic postoperative pain (CPP) remains a disturbing and obscure clinical problem, which
could persist beyond wound healing phase and last for more than 3 months after surgery. The
prevalence of CPP after sternotomy is estimated to be as high as 14%-61%, according to
several recent studies. However, CPP following other types of surgeries has not been well
evaluated. There is paucity of literature regarding the impact of CPP on daily life as well.
Additionally, the identification of predisposing factors for CPP would provide clues for its
prevention and treatment. The aim of present study was to assess the prevalence of CPP,
investigate its impact on life quality and explore its potential risk factors.
After informed consent was signed, patients receiving surgery under general anesthesia during
2018 will be included. The sample size in Peking Union Medical College Hospital is estimated
to be approximately 700. Furthermore, we are trying to contact with other large hospitals in
China to make a multi-center study.
Patients' preoperative information will be collected from medical record, including basic
demographic data, primary disease (tumor size, location and peripheral invasion) and previous
chronic diseases (hypertension, diabetes, coronary heart disease, chronic kidney disease,
anxiety and depression). Intraoperative information will be obtained from anesthesia record,
including surgical scope, duration, length and location of incisions and blood loss.
Postoperative pain control methods can be learned from medical orders. Acute pain will be
evaluated in the ward of the department of surgery before discharge. At the same time, an app
will be installed on patients' mobile phones. Our long-term postoperative follow-up would be
performed by sending out survey questionnaires via this app in the 4th, 8th, 16th, 32th, and
48th weeks after surgery. The survey covers questions regarding the intensity (Wong-Baker
FACES Pain Rating Scale), characteristic, location and impact on daily activities (Brief Pain
Index, BPI) of CPP. Furthermore, information regarding treatment of CPP will also be
collected, if any. All the data obtained from app could be included into our database and
statistically analyzed.
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