Chronic Heart Failure Clinical Trial
Official title:
Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy
The study is performed to consider the effect of thiamine supplementation on symptoms and signs of patients with heart failure and systolic and diastolic function of left ventricle.
The study is performed to consider the effect of thiamine supplementation versus placebo on
symptoms and signs of patients with heart failure systolic and diastolic function of left
ventricle.
Heart failure patients (left ventricular ejection fraction (LVEF ≤ 40%) are randomized to
receive tablets of 300mg or placebo for 1 months in a double-blind fashion. All subjects
will be on stable optimal medical therapy according to the present guidelines for at least 3
months before enrolment. At randomization and at study end, echocardiography by a single
observer will be performed and assessment of symptoms and signs and quality of life based on
self scoring system (from 1 to 7) and objective physical examinations will be done.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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