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NCT00517725 Clinical Trial

Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure

Chronic Heart Failure Clinical Trial

— CARNEBI  

Official title:
Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00517725
Other study ID # R76-CCM S78/407
Secondary ID
Status Completed
Phase Phase 4
First received August 16, 2007
Last updated September 15, 2010
Start date July 2007
Est. completion date May 2010

Study information
Verified date September 2010
Source Centro Cardiologico Monzino
Contact n/a
Is FDA regulated No
Health authority Italy: Ministry of Health
Study type Interventional

Clinical Trial Summary

The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.

Both could influence exercise capacity in normoxic as well as hypoxic conditions.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date May 2010
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Chronic heart failure patients in stable clinical condition

Exclusion Criteria:

- No comorbidity

- NYHA class IV

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• carvedilol

• bisoprolol

• Nebivolol

Locations
Country Name City State
Italy Centro Cardiologico Monzino, University of Milan Milan

Sponsors (1)
Lead Sponsor Collaborator
Centro Cardiologico Monzino

Country where clinical trial is conducted

Italy, 

References & Publications (1)

Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary exercise capacity two months
Secondary lung diffusion two months
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