Clinical Trials Logo
  1. Home
  2. Other
  3. NCT00205647

Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis

Chronic Bronchitis Clinical Trial

Official title:
A Phase II Multicenter Efficacy, Safety and Dose-Effect Study of the Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable, Chronic Bronchitis

Clinical Trial Summary

This is a randonmized, masked, placebo-controlled parallel group, clinical trial to evaluate the effects of three different doses of N-acetyl L-cysteine (NAC) and placebo on patient safety and on physical and transport properties of expectorated sputum. Patient sumptoms, quality of life and exacerbation will also be followed as well as pulmonary function testing and functional exercise capacity. We hypothesized that a prolongeed course of oral NAC favorably affects the morbidity of chronic bronchitis, particularly the incidence of acute exacerbations.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00205647
Study type Interventional
Source Wake Forest University Health Sciences
Contact
Status Completed
Phase Phase 2
Start date January 1997
Completion date March 2000
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT05533931 - Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis N/A
Completed NCT01420445 - Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis Phase 2
Completed NCT01071161 - The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough Phase 3
Terminated NCT00524095 - Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis Phase 2
Completed NCT00903955 - Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease N/A
Completed NCT00129883 - Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals N/A
Recruiting NCT05075083 - Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Elderly People With Chronic Bronchitis and COPD Phase 4
Recruiting NCT05075057 - Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Patients Aged ≥60 Years With Chronic Bronchitis and COPD Phase 4
Terminated NCT02838108 - The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort
Completed NCT02128529 - Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD) N/A
Withdrawn NCT00298402 - Macrophages in Smokers' Lung N/A
Completed NCT00298389 - Macrophage Phagocytosis in COPD
Terminated NCT00132951 - KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Community-acquired Lower Respiratory Tract Infections Phase 4
Active, not recruiting NCT01969344 - Study of COPD Subgroups and Biomarkers
Completed NCT00680056 - Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients Phase 4
Completed NCT00106080 - Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD) N/A
Completed NCT00042718 - A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis. Phase 3
Completed NCT02099799 - The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD N/A
Completed NCT00342030 - Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans N/A
Withdrawn NCT02341183 - Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects N/A