Retinal Detachment Clinical Trial
Official title:
Changes of Macular Pigment Optical Density and Parameters After Nd: YAG Laser Posterior Capsulotomy in Cases With Posterior Capsule Opacification
It has been hypothesized that potential effects of laser Nd: YAG laser posterior capsulotomy may affect macular pigment as well as choroidal thickness, macular thickness and anterior chamber parameters, so it was aimed to investigate possible effects of Nd: YAG laser posterior capsulotomy on macular pigment optical density, choroidal thickness, macular thickness and anterior chamber parameters in cases with posterior capsule opacification in this study.
This clinical trial was conducted following the principles of the Declaration of Helsinki.
The local authorized clinical trials ethics committee approved the protocol and consent forms
(Afyon Kocatepe University Clinical Trials Ethics Committee, 2011-KAEK-2 2017/172). Between
2015 and 2016, 38 pseudophakic participants were enrolled in this study. After providing
information to patients about the disease and treatment, patients predicted to show adherence
to treatment, were enrolled in the study.
Detailed ophthalmological examinations of all subjects were performed prior to Nd: YAG laser
posterior capsulotomy intervention. Anterior chamber parameters of cases with PCO were
measured Measurements of IOP, anterior chamber parameters, visual acuity, Slit-lamp,
gonioscopy and fundus examinations, and measurements of central macular thickness (CMT),
choroidal thicknesses (CTs), and MPOD were performed after maximal pupil dilatation.
Proposed procedure, including risks, beneļ¬ts, and alternatives were discussed with all
subjects, and all participants signed of informed consent form.
Choroidal thicknesses were recorded as subfoveal CT (SCT), nasal CT (NCT) and temporal CT
(TCT).
MPOD measurements were subsequently made by using luminance differential thresholds test.
After measurements a refractive surgery specialist carried out Nd: YAG laser posterior
capsulotomy interventions to patients who were decided to applying Nd:YAG laser capsulotomy.
All examinations and measurements were repeated and recorded at 1st week, 1st and 2nd month.
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