Clinical Trials Logo
  1. Home
  2. Children
  3. NCT05619640

The Potential Role of sRAGE, KL-6, and SP-D as Prognostic Factors in Children With COVID-19

Children Clinical Trial

Official title:
The Potential Role of Receptor for Advanced Glycation End-Products, Serum, Krebs Von Den Lungen-6, and Surfactant Protein D as Prognostic Factors in Children With Severe Acute Respiratory Syndrome (SARS-CoV-2)

Clinical Trial Summary

COVID-19 causes a wide spectrum of clinical illness, from upper respiratory symptoms to severe respiratory failure and death. Several plasma biomarkers -such as IL-6, C-reactive protein (CRP), D-dimer, the neutrophil-to-lymphocyte ratio, and ferritin, among others- have been studied as markers of disease severity and prognosis. Besides, as alveolar damage biomarkers such as Surfactant protein D (SP-D), Krebs von den Lungen-6 (KL-6), and soluble Receptor for Advanced Glycation end products (sRAGE) can be used in lung diseases as well as COVID-19 pneumonia. The investigators hypothesized that serum SP-D, KL-6 and sRAGE levels increases in the setting of COVID-19 pneumonia. In this prospective study the investigators aimed to determine the clinical value of serum KL-6, SP-D and sRAGE levels as a prognostic marker in children with COVID-19 patients. In the literature review, it has been determined that there is no study conducted or published in pediatric patients for this purpose, and it is aimed that our study will be a pioneer study on this subject.

Clinical Trial Description

It aimed to determine the clinical value of serum KL-6, SP-D and sRAGE levels as a prognostic marker in children with COVID-19 patients.. This study was planned as a case-control study with patients hospitalized in the Haseki Training and Research Hospital Pediatric Infection Ward. A total of 150 children, including at least 30 patients in each group were included in the study. The study group was divided into three groups according to COVID-19 WHO clinical progression Scale: uninfected (Group 1), mild (Group 2) and moderate (group 3). In order to investigate the relationship between disease severity and alveolar damage, serum KL-6, SP-D and sRAGE levels and high sensitive C-reactive protein were measured. These biomarkers levels were compared between three groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05619640
Study type Observational [Patient Registry]
Source Haseki Training and Research Hospital
Contact
Status Completed
Phase
Start date July 1, 2021
Completion date September 30, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT03563196 - Diagnosis Of Pulmonary Complications After Cardiac Surgery In Children
Completed NCT02553486 - Internationally Adopted Children Quality of Life N/A
Completed NCT02903134 - Early Risk of Asthma in Children Exposed to In-utero Maternal Obesity
Completed NCT02918890 - Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia N/A
Active, not recruiting NCT01874847 - PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin Phase 2/Phase 3
Enrolling by invitation NCT01971827 - Effectiveness of a Physical Activity Intervention to Prevent Obesity and Improve Academic Performance N/A
Enrolling by invitation NCT01971840 - Effectiveness of a Physical Activity Intervention on Preventing Obesity During the Adiposity Rebound Period. N/A
Completed NCT01738308 - The Effects of Healing Touch on Post Operative Pediatric Patients N/A
Completed NCT01693926 - Effect of Physical Activity an Stress in Children N/A
Completed NCT01943760 - Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty Phase 4
Completed NCT01864811 - Effect of Baby-CIMT in Infants Younger Than 12 Months N/A
Completed NCT01323010 - Efficacy and Safety of Increasing Doses of Inhaled Albuterol in Children With Acute Wheezing Episodes N/A
Completed NCT01277224 - Effectiveness of a Physical Activity Intervention on the Obesity of Schoolchildren N/A
Active, not recruiting NCT00989547 - Cord Blood Infusion for Type 1 Diabetes Mellitus (T1DM) Phase 1
Completed NCT04051723 - Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children Phase 4
Completed NCT03236337 - Effectiveness of MOVI Interventions on Adiposity, Cognition and Subclinical Atherosclerosis: MOVI-daFit! N/A
Completed NCT03236363 - Effectiveness of MOVI Interventions on Adiposity, Cognition and Motor Competence: MOVI-da10! N/A
Not yet recruiting NCT03427697 - Effect of VR and Accommdation Relax on Controlling Myopia in Children N/A
Completed NCT05603507 - Inspiratory Muscle Training in Children With Chest Burn N/A
Not yet recruiting NCT06267339 - Effects of Transcranial Random Noise Stimulation on Motor Learning in Typically Developing Adolescents Early Phase 1