Early Risk of Asthma in Children Exposed to In-utero Maternal Obesity

Status Completed

Clinical Trial Summary

This study seeks a better understanding of the pathogenesis of asthma in early life. The aim of this project is to determine whether the offspring of obese mothers at 3 years of life have increased the risk of asthma compared to children whose mothers were not obese and whether this increased risk is associated with a programming altered immune reactivity at birth.

Clinical Trial Description

The general objectives of this study are: 1. To determine whether the increased risk of asthma in children born from a pre-pregnant obese mother can be observed at 3 years of life and whether this increased risk associated with altered plasma levels of immune mediators at birth. 2. To explore in children born from pre-pregnant obese mother whether monocyte physiology and M1-M2 polarization present an altered response and expression of asthma-related immune-modulations at birth. 3. To study in neonates born from pre-pregnant obese mother whether the in vitro expression of TNFα, IL12, IL-10 and IL-4Rα in monocytes associates with changes in the DNA methylation status in the promoter regions of those genes. The study is performed in accordance with the Helsinki Declaration, and the study protocol was accepted by Institutional Review Boards at School of Medicine of the Pontificia Universidad Católica de Chile. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02903134
Study type	Observational
Source	Pontificia Universidad Catolica de Chile
Contact
Status	Completed
Phase
Start date	September 2014
Completion date	June 2018

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