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LIMIT Early Adiposity Rebound in Children — LIMIT  

Childhood Obesity Clinical Trial

Official title:
LIMIT (LIfestyle and Microbiome InTeraction) Early Adiposity Rebound in Children

Clinical Trial Summary

Childhood obesity is a strong predictor of adult obesity with health and economic consequences for the individual and society. Adiposity rebound (AR) is a rise in the Body Mass Index occurring between 3-7 years. Early adiposity rebound (EAR) occurs at a median age of 2 years and is a risk factor for later obesity. Events happening in "the first 1,000 days" play a role in obesity development. One of the key elements in this crucial time window is the gut microbiome, a highly dynamic organ that is sensitive to environmental exposure being linked to obesity development. Prenatal (dietary/lifestyle maternal factors and environmental exposure) and postnatal determinants (the type of feeding, sleep patterns, speed of growth) and environmental obesogenic pollutants may influence the infant microbial colonization, thus increasing the risk of EAR onset. LIMIT will holistically identify the longitudinal interplay between the intestinal microbiome and infant/maternal nutritional and lifestyle habits, environmental factors exposure and anthropometric measurements, in children with AR vs EAR, driving new mechanistic insights to create an EAR predictive model. The study will evaluate a group of 150 mother-infant pairs, during the first four years of life at different follow-up.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04960670
Study type Observational
Source University of Pavia
Contact Ilaria Di Napoli, Dr
Phone +390382987536
Email ilaria.dinapoli@unipv.it
Status Not yet recruiting
Phase
Start date December 1, 2021
Completion date December 31, 2026
View Details
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