Early Childhood Obesity Programming by Intrauterine Growth Restriction

Status Recruiting

Clinical Trial Summary

The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.

Clinical Trial Description

Epidemiological studies of multiple cohorts suggest an increased risk for obesity, cardiovascular disease-related death and type 2 diabetes in low birth weight infants. However, the molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Alterations in DNA methylation during fetal life have been proposed to be one of the mechanisms that regulate this phenotype. Here, the investigators address major questions about early childhood obesity programming by studying purified subpopulations of CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life. The investigators will correlate altered CD3+ T-cell DNA methylation profiles in cord and peripheral blood samples and functional changes in CD3+ T-cells with adiposity in childhood. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03402139
Study type	Observational
Source	Montefiore Medical Center
Contact	Mamta Fuloria, MD
Phone	718-904-4105
Email	mfuloria@montefiore.org
Status	Recruiting
Phase
Start date	September 1, 2018
Completion date	March 2028

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