Childhood Obesity Clinical Trial
Official title:
Co-existent OSA and Obesity: Finding NEAT Targets for Intervention
Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea
(OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of
life, and premature death. While the complex interactions between obesity and OSA are not
entirely clear, we hypothesize that these conditions may compound each other by:
1. decreasing physical activity and total energy expenditure by reducing both non-exercise
physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical
activity.
2. alterations in the secretion of appetite-controlling hormones, which may lead to
increases in energy intake.
Objective: To determine whether the presence of both obesity and OSA in children is
associated with a decrease in physical activity and alterations in appetite-regulating
hormones greater than those seen in either condition alone or compared to controls.
Methods: Comparison of children 10-17 years with obesity and OSA, obesity alone, OSA alone
and neither condition, for the following outcomes: (1) NEAT (kcal/day) (2) Physical activity
behavior, appetite regulating hormone profile and self-report appetite assessment.
Unique Aspects: This study combines expertise in sleep medicine, exercise physiology and
obesity. Conclusions from this study will better characterize this high-risk clinical
population so that innovative strategies targeting improvements in lifestyle behaviors can be
developed.
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