lncRNA-based Nomogram to Assist Childhood Asthma Diagnosis

Childhood Asthma Clinical Trial

Official title:

LncRNA and Predictive Model to Improve the Early Diagnosis of Childhood Asthma

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT04525586
• Other study ID #: LLJ1.0
• Status: Withdrawn
• Start date: December 31, 2021
• Est. completion date: September 30, 2022

Study information

• Verified date: December 2022
• Source: Children's Hospital of Fudan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Asthma is the most common chronic disease in children, however, underdiagnosis of childhood asthma is an important issue in asthma management. The lack of reliable and objective diagnostic indicators requires the development of rapid and accurate strategies for the early diagnosis of childhood asthma. Recent studies have found a correlation between long-chain non-coding RNA (lncRNA) expression and childhood asthma, suggesting that lncRNA may be a potential biomarker for asthma diagnosis.

Description:

The investigators envision exploring the early diagnosis of asthma by combining lncRNA with electronic medical records. In this project, the investigators will combine high-throughput sequencing, asthma case database, electronic medical record and informatics to investigate the feasibility of combining lncRNA with electronic medical record for asthma diagnostic model. The expected results will establish the foundation for the diagnosis and treatment of childhood asthma and open up new ideas.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: September 30, 2022
• Est. primary completion date: September 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 2 Years to 5 Years

Eligibility

Inclusion Criteria:

children with recurrent wheezing

Exclusion Criteria:

1. diagnosis of other chronic respiratory disease (e.g. cystic fibrosis, bronchopulmonary dysplasia, etc)

2. immunodeficiency- acquired or congenital

3. neuromuscular disease

4. congenital heart disease

Related Conditions & MeSH terms

• Asthma
• Childhood Asthma

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Children's Hospital of Fudan University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	rate of early diagnosis of childhood asthma	a diagnosis of transient wheeze or asthma was made by a pediatric pulmonologist. This classification was based on symptoms, use of asthma medication, and lung function features.	24 months