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Childhood Asthma clinical trials

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NCT ID: NCT05390554 Completed - Childhood Asthma Clinical Trials

Using Buteyko Breathing Technique to Control Asthma in School-Age Children

Start date: September 15, 2019
Phase: N/A
Study type: Interventional

Asthma is a complex condition that can impair not only the child's physical growth but also his optimal functional capacity and performance. Buteyko Breathing Technique (BBT) is an exercise designed to regulate the breathing process. The Buteyko technique also proposes lifestyle changes beyond breathing, including diet, allergy avoidance, and stress control. This study aims to evaluate the effect of the Buteyko breathing technique on asthma severity control among school-age children. In Egypt, this technique was applied through five studies, four among adult patients and only one among children. At Mansoura University, only one study was conducted among adult patients, and no studies were conducted among children. To fulfill this knowledge gap, it is necessary to study the effect of this technique on asthma severity control among school-age children. This study will use the Childhood Asthma Control, Peak Expiratory Flow Rate, and Control Pause tests to evaluate the children's asthma severity control.

NCT ID: NCT05105386 Not yet recruiting - Clinical trials for Environmental Exposure

The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing

SynAir-Child
Start date: September 2023
Phase:
Study type: Observational [Patient Registry]

To quantify health effects of synergizing chemical and biological pollutants in a targeted population setting, i.e., school-aged children. Indoor air pollutants will be monitored within the classrooms with high end sensors. Exposure data from additional sources (outdoor, home, transports) will be obtained. Health outcomes will be assessed prospectively using validated medical procedures and real-time tracking with mobile health (mHealth) equipment and a gamified computer app.

NCT ID: NCT05066841 Recruiting - Childhood Asthma Clinical Trials

Chinese Herbal Medicine Formula Combined With Inhaled Corticosteroids for the Treatment of Mild to Persistent Asthma in Children

Start date: September 25, 2021
Phase: N/A
Study type: Interventional

The purpose of study is to provide an objective data for evaluating the efficacy and safety of Chinese medicine (CM) formula combined with inhaled corticosteroid in the treatment of asthmatic children. Investigators will recruit eighty-six mild to moderate asthmatic children aged 4-11 years old with regular ICS usage and they will be randomized into two groups in this double-blind trial. Forty-three subjects will receive CM (CM group; Ma-Hsing-Kan-Shih-Tang in combination with Liu-Jun-Zi-Tang) and the other forty-three subjects will receive placebo (placebo group; 10% CM) for 12 weeks. Investigators will compare these two groups by questionnaires of Childhood Asthma Control Test (cACT), the Integrated Therapeutics Group Child Asthma Short Form (ITG-CASF), Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), the pulmonary function test and blood test including Complete Blood Count with Differential Count (CBC/DC), total IgE, Eosinophil Cationic Protein (ECP) and IL-4/IL-5/IL-13. Adverse events, renal and liver function test will be evaluated to investigate the safety of CM formula as well.

NCT ID: NCT05064579 Completed - Childhood Asthma Clinical Trials

Towards an Algorithmic Approach to Asthma Management: Collaborative Definition of Algorithm Objectives With Families

COPA
Start date: January 18, 2022
Phase:
Study type: Observational

Using "big data" and artificial intelligence techniques, it becomes possible to envision algorithms for managing childhood asthma on a daily basis. In order to develop such tools, it is necessary to determine with asthma stakeholders (children, parents, doctors) the parameters that future algorithms should seek to maximize / minimize. The main objective of the study is to quantify the respective importance of each of the goals that children with asthma, parents, and their doctors seek to achieve when taking / supervising / prescribing a background therapy.

NCT ID: NCT04942379 Completed - Childhood Asthma Clinical Trials

Asthma Link: A Real World Application of School Supervised Asthma Therapy

Start date: August 10, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to assess the feasibility of a clinical trial to evaluate the impact and process of deploying school-supervised asthma therapy in a real-world setting for children with poorly controlled asthma (aged 6-17 years).

NCT ID: NCT04617015 Completed - Depression Clinical Trials

Defining and Treating Depression-related Asthma

Start date: September 9, 2016
Phase: Early Phase 1
Study type: Interventional

Depression is seen more often in people with asthma, and may lead to increased development and severity of asthma. This study will investigate whether children with depression and asthma have less allergic disease and less inflammation than children with asthma who do not have symptoms of depression. The study will also investigate whether the lungs of children with depression and asthma respond to an anticholinergic inhaler called ipratropium more than the lungs of non-depressed asthmatic children.

NCT ID: NCT04525586 Withdrawn - Childhood Asthma Clinical Trials

lncRNA-based Nomogram to Assist Childhood Asthma Diagnosis

Start date: December 31, 2021
Phase:
Study type: Observational

Asthma is the most common chronic disease in children, however, underdiagnosis of childhood asthma is an important issue in asthma management. The lack of reliable and objective diagnostic indicators requires the development of rapid and accurate strategies for the early diagnosis of childhood asthma. Recent studies have found a correlation between long-chain non-coding RNA (lncRNA) expression and childhood asthma, suggesting that lncRNA may be a potential biomarker for asthma diagnosis.

NCT ID: NCT04250779 Recruiting - Asthma Clinical Trials

Evaluating Efficacy of Smart Device in Assisting With Inhaler Technique and Adherence

MOMMIASTHMA1
Start date: July 1, 2019
Phase: Early Phase 1
Study type: Interventional

Asthma affects over 10 million children in the U.S., and poses a significant health and cost burden. Metered dose inhaler (MDI) is the most common method of treatment. Studies show that up to 80% of patients demonstrate incorrect use of MDIs, which results in suboptimal medication delivery to the lungs. Asthma control can be followed by symptoms, rescue medication usage and measures of airflow obstruction. Current options to monitor control include an asthma diary (relies on consistent use by the patient), pharmacy records of medication dispensing (dispensing does not equal usage), and peak expiratory flow (PEF) meters (significant variability in technique leading to inconsistent results). CapMedic is a smart inhaler and home spirometer device which aims to assist with correct MDI usage and to monitor asthma control. CapMedic fits on top of the MDI inhaler and provides live audio-visual-haptic cues to guide the patient for correctly using their inhaler. CapMedic includes a built-in forced expiratory flow in 1 second (FEV1, a measure of airflow) and PEF meter. It will utilize the same audio-visual-haptic hardware to implement live cues that encourage patient's effort in performing accurate at-home FEV1/PEF test. Cap will also be able to log medication usage and Medic application will allow patients to keep an asthma symptom diary.

NCT ID: NCT04089085 Active, not recruiting - Childhood Asthma Clinical Trials

STRONGer Together: A Small Group Intervention for Children With Asthma and Anxiety/Depression

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

The proposed study is a one group pilot to assess the feasibility and acceptability of an 8-session intervention (STRONGer Together) for children between 8 - 12 years of age with asthma and anxiety/depressive symptoms.

NCT ID: NCT03696602 Completed - Childhood Asthma Clinical Trials

More Relaxation by Deep Breath on Methacholine

SouProvocBro
Start date: July 1, 2006
Phase:
Study type: Observational

Deep inhalation (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation. The hypothesis tested was that DI induces more relaxation in methacholine induced bronchoconstriction—solely determined by the smooth muscle contraction—than in exercise induced bronchoconstriction, which is contributed to by both smooth muscle contraction and airway wall inflammation.