General Risk Factors and Inflammatory Determinants in Older Patients With Asthma — GRANDMA  

Asthma Clinical Trial

Official title: General Risk Factors and Inflammatory Determinants in Older Patients With Asthma

Status Completed

Clinical Trial Summary

A cross-sectional study in asthma patients to determine if a late age of onset asthma (start symptoms >18 years old), is associated with more persistent airway/systemic inflammation, worse asthma control, more co-morbidity, a different microbiome and poorer quality of life despite the use of optimized asthma therapy.

Clinical Trial Description

For ages, asthma has been considered a disease for children and young adults. However, nowadays 30% of all asthma patients is over 50 years old. Asthma in the elderly is generally more severe and approximately 50% of all deaths drom asthma occur in this age group. With rapid aging of the global population, the burden of asthma in the elderly will further increase.

Asthma is a heterogeneous disease and the question is whether asthma in the elderly can be considered the same disease as asthma in children and young adults. The pathophysiology and risk factors of asthma in the elderly are still not completely understood. Good characterization of asthma in the elderly requires clinical phenotyping as well as a thorough analysis of the underlying cellular and molecular mechanisms. It is hypothesized that in older asthma patients, a late age of onset (start asthma symptoms >18 years) is associated with more persistent airway/systemic inflammation, worse asthma control, more co-morbidity and poorer quality of life despite the use of optimized asthma therapy. ;

Related Conditions & MeSH terms

• Asthma
• Childhood Asthma
• Late-Onset Asthma

• NCT number: NCT03278561
• Study type: Observational
• Source: Franciscus Gasthuis
• Status: Completed
• Start date: May 8, 2017
• Completion date: December 31, 2019