Cerebral Amyloid Angiopathy Clinical Trial
Official title:
F-18-AV-45 Uptake, Spot Sign Presence and Cerebral Amyloid Angiopathy (CAA) in Primary Intracranial Hemorrhage (ICH)
Florbetapir F 18 is an experimental radioactive drug that may allow doctors to image changes
in the brain using a PET (Positron Emission Tomography) scanner. The purpose of this study
is to evaluate the imaging characteristics of, Florbetapir F 18 (also known as 18F-AV-45) in
patients who have previously undergone bleeding in their brains. Florbetapir F 18 binds to
amyloid-ß peptide (Aß) that accumulates in the brains of patients with bleeding. These
accumulations are called amyloid plaques and when extensive are labeled cerebral amyloid
angiopathy (CAA). Florbetapir F 18 sticks to the amyloid plaques in the brain and emits a
low level of gamma rays which can be detected by a PET camera.
MRI detected microbleeds have been identified as markers of clinically silent hemorrhage
from bleeding-prone vessels. Another imaging marker of vessel damage and risk of bleeding is
the spot sign (SS). Finally, certain genetic signatures (ApoE genotype) have been shown to
be associated with Aß deposition in the brain or predispose patients to higher risks of
bleeding. This research study will explore the interactions of these factors and understand
the physiology of intracerebral bleeding.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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