Cerebral Amyloid Angiopathy Clinical Trial
Official title:
SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA): Italian Network for the Study of CAA
Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease,
and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly
patients. Although increasingly detected, a number of aspects including the pathophysiology,
the clinical and neuroradiological phenotype and the disease course are still under
investigation. The incomplete knowledge of the disease limits the implementation of evidence
based guidelines on patient's clinical management and the development of treatments able to
prevent or reduce disease progression.
The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian
multicentre cohort study aimed at better defining the disease natural history and identifying
clinical and neuroradiological markers of disease progression. By a multidisciplinary
approach and the collection of a large and well phenotyped series and biorepository of CAA
patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA
pathophysiological mechanisms.
The SENECA is an Italian multicenter network integrating the experience of neurologists, neuroradiologists, neuro-ophthalmologists and biologists and allowing the standardized collection of a well-characterized wide series of sporadic and familial CAA patients. ;
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|---|---|---|---|
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Phase 1/Phase 2 | |
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| Withdrawn |
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N/A |