Impact of Tegaderm HP and CHG in Major Catheter Related Infections and Dressing Detachment — DRESSING2  

Catheter-Related Infections Clinical Trial

Official title: Impact of Tegaderm HP and Tegaderm CHG in Major Catheter Related Infections and Dressing Detachment in ICU Patients a Prospective Randomized Study

Status Completed

Clinical Trial Summary

Catheter related infection is a frequent and life threatening event in ICU. A chlorhexidine impregnated sponge has been proven to reduce the rate of major catheter related infections in ICU patients (HR=0.39, p=0.03) (Timsit Jama 2009). However, dressings are detached in 40% of cases before planned changes and the rate of unplanned dressing is significantly associated with the major catheter related infections.

Primary objective: To demonstrate that Tegaderm CHG, a new CHG impregnated dressing decrease the rate of major catheter related infection as compared to non impregnated dressings and to demonstrate that highly adhesive dressing decrease the rate of detached dressings.

Secondary objectives:

• To demonstrate that the use of high performance dressing decrease the rate of unstuck dressing and the rate of catheter infections.

• To evaluate the tolerance of CHG impregnated gel dressings (Tegaderm CHG).

• To calculate the cost saving of each dressings

Clinical Trial Description

Inclusion criteria: Patients older than 18 years old with central venous who need a central vein and/or an arterial catheter for an expected duration of more than 48 hours. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Catheter-Related Infections
• Infection

• NCT number: NCT01189682
• Study type: Interventional
• Source: University Hospital, Grenoble
• Status: Completed
• Phase: Phase 4
• Start date: April 2010
• Completion date: July 2011