Cataract Clinical Trial
Official title:
The Effects of Ripasudil in Patients With Fuchs Endothelial Corneal Dystrophy Undergoing Femtosecond Laser Assisted Cataract Surgery
The purpose of this research is to investigate the effects of ripasudil administered as an ophthalmic solution in patients with FED after femtosecond laser assisted cataract surgery. The secondary aim is to identity the characteristics of patients who will benefit the most with the use of ripasudil based on the test results obtained from this study.
Patients with Fuch's Corneal Endothelial Dystrophy and undergoing femtosecond laser-assisted cataract surgery will be recruited for this study. They will be randomly assigned into treatment or placebo group. The investigators hypothesize that the ROCK inhibitor ripasudil 0.4% helps maintain corneal endothelial functional integrity and reduce cell loss after cataract surgery in patients with FED. To test the hypothesis, the investigators plan to conduct a randomized clinical trial which aims to: 1. Evaluate the clinical outcomes of FED eyes following FLACS with and without ripasudil 0.4% 2. To identity which FED patients will most likely benefit from the use of ripasudil 0.4% based on pre-operative parameters 3. To monitor for any adverse effects in patients assigned to ripasudil 0.4% ;
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