Caffeine Consumption and Cataract Prevention

Cataract Clinical Trial

Official title:

The Impact of Caffeine Consumption on Preventing Cataract

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05194696
• Other study ID #: CaffQuest
• Status: Recruiting
• Start date: September 1, 2020
• Est. completion date: September 1, 2025

Study information

• Verified date: January 2022
• Source: Vienna Institute for Research in Ocular Surgery
• Contact: Martin Kronschläger, PhD
• Phone: 01 91021
• Email: office[@]viros.at
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Effect of peroral caffeine consumption on the delay of cataract onset.

Description:

Several experimental studies have shown that caffeine inhibits cataract development by scavenging reactive oxygen species. Evidence from epidemiological studies, however, is controversial. Varma et al., found that the incidence of cataract blindness in humans was significantly lower in groups consuming higher amounts of coffee in comparison to the groups with lower coffee intake. Moreover, Rautiainen et al. showed that the dietary total antioxidant capacity including coffee of middle-aged and elderly women was inversely associated with the risk of age-dependent cataract. Another population-based study involving the population residing in Beaver Dam, Wisconsin, did not find a meaningful association between 10-year cumulative incidence of cataract and the amount of caffeine intake.

Although cataracts can be surgically removed, barriers that prevent access to surgery are a problem in many countries. Moreover, no prophylactic treatments are currently available to prevent the onset of cataract. Yet estimates indicate that a delay of only 10 years in the onset of cataract could reduce the need for cataract surgery by as much as 50%.

The present study aims to investigate whether peroral caffeine consumption on a regular daily basis for a significant period of time and sufficient dose delays cataract development.

12000 eyes of 6000 patients will be included into this study. Patient will have to fill out a questionnaire for caffeine consumption habits during lifetime and risk factors for cataract development. Further, a complete ophthalmic examination, cataract grading, refraction, visual testing, and biometry will be performed.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 12000
• Est. completion date: September 1, 2025
• Est. primary completion date: September 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years to 105 Years

Eligibility

Inclusion Criteria:

• age older than 21 years

• cataract

Exclusion Criteria:

• age younger than 21 years

Related Conditions & MeSH terms

• Cataract

Intervention

Behavioral:
• Questionnaire
Patients have to answer a questionnaire about their caffeine consumption habits during lifetime

Locations

Country	Name	City	State
Austria	Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
Vienna Institute for Research in Ocular Surgery

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Caffeine consumption	Caffeine consumption will be assessed using a questionnaire concerning the caffeine drinking habits	48 months