Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery

Cataract Clinical Trial

— ECOCHI  

Official title:

Correlation Between Postoperative Central Corneal Thickness and Endothelial Damage After Cataract Surgery by Phacoemulsification

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03972670
• Other study ID #: 2018-13Obs-CHRMT
• Status: Completed
• Start date: August 1, 2014
• Est. completion date: January 1, 2018

Study information

• Verified date: May 2019
• Source: Centre Hospitalier Régional Metz-Thionville
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To study correlation between postoperative corneal edema and endothelial cell loss after cataract surgery by microcoaxial phacoemulsification.

Description:

Cataract surgery facilitates improved visual acuity through extraction of an opacified lens, followed by intraocular lens implantation. An average adult cornea has 2000 to 2500 cells/mm2, a count that diminishes with age with a rate of attrition of approximately 0.3% to 0.5% per year. Long-term postoperative corneal transparency depends on the morphological stability and functional integrity of the corneal endothelium. It is well established that all surgical interventions that require entry into the anterior chamber result in some damage to the corneal endothelium.

Endothelial cell loss results in cell hypertrophy to maintain continuity, resulting in a change in endothelium cell density and morphology. Many studies have assessed the impact of various surgical techniques on endothelial damage and numerous studies have investigated the factors influencing endothelial cell loss after phacoemulsification. The goal of this study is to investigate the correlation of postoperative corneal edema with the reduction of endothelial corneal cell density after phacoemulsification.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 85
• Est. completion date: January 1, 2018
• Est. primary completion date: November 30, 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• The presence of senile cataract with equivalent grades and a history of visual acuity regression

Exclusion Criteria:

• Patient with total white cataract

• With history of ocular surgery

• With other eye diseases (corneal pathology, Fuchs dystrophy, uveitis and glaucoma) or systemic diseases (diabetic disorder and dementia)

Related Conditions & MeSH terms

• Capsule Opacification
• Cataract
• Phacoemulsification

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Régional Metz-Thionville

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pachymetry	Measurement of the thickness of the eye's cornea with a pachymeter	Day 1
Secondary	Endothelial cell density	Endothelial cell density measurements with noncontact specular microscope	Day 1
Secondary	Pachymetry after 1 month	Measurement of the thickness of the eye's cornea with a pachymeter	Day 30
Secondary	Endothelial cell density after 1 month	Endothelial cell density measurements with noncontact specular microscope	Day 30