The Pathogenesis of Human Senile Cataract

Cataract Clinical Trial

Official title:

The Pathogenesis of Age-related Cataract

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03907358
• Other study ID #: Shanghai1st-cataract-001
• Status: Recruiting
• Start date: December 7, 2016
• Est. completion date: June 30, 2020

Study information

• Verified date: April 2019
• Source: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
• Contact: Haidong Zou
• Phone: 86-21-63240090
• Email: zouhaidong[@]hotmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

Description:

Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: June 30, 2020
• Est. primary completion date: December 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 94 Years

Eligibility

Inclusion Criteria:

• Patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery.

Exclusion Criteria:

• Patients whose cataracts need not be operated

• Patients with any contraindications to cataract surgery

• Patients are unwilling to undergo cataract surgery

Related Conditions & MeSH terms

• Cataract

Intervention

Procedure:
• phacoemulsification

Locations

Country	Name	City	State
China	Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Characterization of miRNA in micro-scale human aqueous humor	method development for miRNA detection in aqueous humor	12 month
Primary	Favored amplification recovery via protection-chromatin immunoprecipitation-Seq of human eye tissue samples	low-cell-number epigenome profiling for study of cataract	24 month
Primary	Study of cataract by genomics, transcriptomics, and proteomics approaches	detect histone H3 lysine 4 trimethylation (H3K4me3) of aqueous humor of cataract patients by genomics, transcriptomics, and proteomics methods	36 month