Cataract Clinical Trial
Official title:
Aqueous Humour Concentrations After Topical apPlication of combinEd Levofloxacin-dexamethasone Eye dRops and of Its Single Components: a randoMized, assEssor-blinded, Parallel-group Study in Patients Undergoing Cataract Surgery - iPERME
The purpose of this study is to evaluate the penetration of levofloxacin and dexamethasone 21-phosphate into the aqueous humour after ocular administration in combination or as single active ingredients.
In most cases, postoperative care after cataract surgery consists of antiinflammatory and
antibacterial drug therapy. The use of an ophthalmic solution containing the combination of a
steroid and an antibiotic is routinely used in clinical practice; however, treatment duration
could favour the emergence of antibiotic resistance. The study treatment associating a
broad-spectrum antibiotic with a highly effective corticosteroid that can be used for a short
period of time (one week) is therefore of considerable interest.
The aim of this study is to measure the concentrations of levofloxacin and dexamethasone in
the aqueous humour after topical application of the combined ophthalmic solution and its
single components.
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