Meibomian Gland Dysfunction (MGD) and Tear Cytokines After Cataract Surgery According to Preoperative Meibomian Gland Status

Cataract Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02411487
• Other study ID #: 4-2014-1103
• Status: Completed
• Phase: N/A
• First received: March 5, 2015
• Last updated: January 23, 2017
• Start date: March 16, 2015
• Est. completion date: August 3, 2015

Study information

• Verified date: January 2017
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To investigate the possible mechanisms by which cataract surgery aggravates meibomian gland dysfunction (MGD), the investigators evaluated the changes in tear cytokines and ocular surface parameters after cataract surgery according to the preoperative MGD grade.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: August 3, 2015
• Est. primary completion date: August 3, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 55 Years to 80 Years

Eligibility

Inclusion Criteria:

• males or non-pregnant females aged between 55 to 80 years-old.

Exclusion Criteria:

• had a history of ocular diseases, such as ocular infection, ocular allergy, and autoimmune disease, as well as patients with continuous use of topical ocular medications before surgery, or histories of ocular surgery or ocular injury.

Related Conditions & MeSH terms

• Cataract

Locations

Country	Name	City	State
Korea, Republic of	Department of Ophthalmology	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (2)

Cyclin-dependent kinase inhibitory protein expression in human choroidal melanoma tumors. Mouriaux F,*(1) Maurage CA, Labalette P, Sablonniere B, Malecaze F, Darbon JM. Inv Ophthalmol Vis Sci 2000;41:2837-2843. Am J Ophthalmol. 2001 Jan;131(1):157. — View Citation

Li XM, Hu L, Hu J, Wang W. Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery. Cornea. 2007 Oct;26(9 Suppl 1):S16-20. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	inflammatory tear cytokine concentration	comparison of tear cytokines (IL-2,4,10,17a, INF-r, TNF-a) concentrations in patients with or without newly diagnosed chronic GVHD after SCT using a multiplex immunobead assay	1 month after cataract surgery
Primary	ocular surface staining		1 month after cataract surgery
Primary	tear film break-up time,		1 month after cataract surgery
Primary	conjunctival injection,		1 month after cataract surgery
Primary	Schirmer's test I		1 month after cataract surgery
Primary	ocular surface disease index		1 month after cataract surgery