Cataract Clinical Trial
Official title:
Limbal Relaxing Incisions Versus Toric Intraocular Lens for Keratometric Astigmatism <2.5 Diopters in Patients Undergoing Cataract Surgery and Intraocular Lens Implantation.
This study will compare toric intra-ocular lens (IOL) with limbal relaxing incisions (LRI)
in correcting astigmatism in patient undergoing standard cataract surgery.
Astigmatism is unequal curvature of the eye; the eye is oval rather than spherical.
Uncorrected astigmatism of greater than approximately 0.75 diopters (D) can cause visual
blurring, ghosting of images or halos. Over 20% of patients undergoing cataract surgery have
astigmatism which is likely to have been corrected by spectacles.
Cataract surgery involves the replacement of the natural opacifying crystalline lens with a
clear artificial plastic intra-ocular lens (IOL). The lens power can be selected to correct
the patient's glasses prescription. The most widely used IOLs only correct glasses at one
distance i.e. either near or distance. Residual astigmatism after cataract surgery will need
glasses for correction which is undesirable for many patients.
Limbal relaxing incisions (LRI) are circumferential partial thickness cuts to the clear
window of the eye (cornea) during surgery. These LRIs can correct corneal astigmatism and
have no additional risk of complications.
Alternatively, toric IOLs are available which correct astigmatism inside the eye. They have
been available for routine use in the last few years; technology has markedly improved and
the lenses have become cheaper.
Studies have suggested toric IOLs provide better vision after cataract surgery than the
regular IOLs. Toric IOL are widely used in the private practice and increasingly in the
National Health Service (NHS). LRIs are cost effective for treating astigmatism however
their predictability is believed to be lower than toric IOLs. As there are no randomised
controlled trials comparing the outcomes between LRIs and toric IOLs. This research will
address this gap in knowledge and accordingly from this research future practice will be
able to provide treatment to patients with information about the best outcomes.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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