The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Cataract Clinical Trial

Official title:

The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT00624039
• Other study ID #: CB2006
• Status: Enrolling by invitation
• Phase: N/A
• First received: February 18, 2008
• Last updated: February 18, 2008
• Start date: May 2006
• Est. completion date: March 2008

Study information

• Verified date: May 2006
• Source: Samsung Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility.

Description:

The functional changes in the ciliary body in presbyopia are not only important in a study of the mechanism for presbyopia but are also a key to various procedures or devices used to restore accommodation. Therefore, it is becoming increasingly important to quantify the in vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before and 2 months after cataract extraction. Images of the ciliary body will be compared visually using Adobe Photoshop 7.0.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 15
• Est. completion date: March 2008
• Est. primary completion date: March 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Age : same or more than 55 years

• Patients with senile cataract who are going to get cataract surgery

Exclusion Criteria:

• Age : less than 55 years

• Previous ocular disease other than cataract.

Study Design

Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Cataract
• Presbyopia

Intervention

Other:
• UBM with pilocarpine in presbyopia
ultrasound biomicroscopic examination in both eyes 30 minutes after one drop of 2% pilocarpine hydrochloride (Ocucarpine®, Samil Pharm., Seoul, Korea) instillation before and two months after cataract surgery

Locations

Country	Name	City	State
Korea, Republic of	Samsung Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (1)

Stachs O, Martin H, Kirchhoff A, Stave J, Terwee T, Guthoff R. Monitoring accommodative ciliary muscle function using three-dimensional ultrasound. Graefes Arch Clin Exp Ophthalmol. 2002 Nov;240(11):906-12. Epub 2002 Oct 9. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ultrasound biomicroscopic findings (ciliary body axial length)		2 months before and after surgery	No