Cataract Extraction Clinical Trial
Official title:
Comparison of Acular LS With Lotemax to Prevent Anterior Segment Inflammation After Phacoemulsification and Intraocular Lens Implantation
The purpose of this study is to compare the effectiveness of Acular LS® and Lotemax® in the prevention of inflammation in the eye after cataract surgery. Acular LS is made by Allergan, Inc. It is a nonsteroidal anti-inflammatory drug (NSAID) and is approved by the Food and Drug Administration (FDA) for use following cataract surgery. Lotemax is made by Bausch & Lomb. It is a steroid and is also approved by the FDA for use following cataract surgery.
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAIDs) which, when
administered systemically, has demonstrated analgesic, anti-inflammatory, and anti-pyretic
activity. The mechanism of its action is thought to be due to its ability to inhibit
prostaglandin biosynthesis (cyclo-oxigenase inhibitors). However, they leave the lipoxygenase
pathway free to generate leukotrienes. This pharmacodynamic activity has been speculated as a
reason why NSAIDs produce less ocular side effects than corticosteroids. It has been widely
used in ophthalmology. In 1987, Flach1 published its effectiveness in the treatment of
aphakic and pseudophakic macular edema. Its efficacy after cataract surgery has been shown2
and it has been compared to topical steroids after extra-capsular cataract extraction3,4,5
and phacoemulsification6,7. It has been used as analgesic after radial keratotomy(RK)8,9,
photorefractive keratectomy (PRK)10 and laser in situ keratomileusis (LASIK)11
The purpose of this study is to compare the effectiveness of the NSAID ketorolac tromethamine
ophthalmic solution 0.4% with the steroid loteprednol etabonate ophthalmic suspension 0.5%
for preventing anterior segment inflammation after routine cataract surgery.
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