Cartilage Injury Clinical Trial
Official title:
Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury
Verified date | September 2023 |
Source | Xijing Hospital |
Contact | Yanyan Jia |
Phone | +862984771794 |
xiyyllwyh[@]163.com | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 60 Years |
Eligibility | Inclusion Criteria: - The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint. - The preoperative routine tests and examinations revealed no contraindications. - Revised sentence: "Informed consent of the patient Exclusion Criteria: - The platelet count or function exhibits significant abnormalities?Systemic infection transmitted through the bloodstream. - Prolonged usage of anti-inflammatory drugs and systemic corticoid administration. - In injection site or damage to the skin. - Patients with tumors or undergoing radiotherapy and chemotherapy. - Pregnant or breastfeeding women. - Individuals with mental illnesses who are unable to cooperate with follow-up procedures. - Contraindications for MRI?Patients or their families do consent to participate in the study. - Other circumstances that render participation in the study unsuitable. |
Country | Name | City | State |
---|---|---|---|
China | Xijing Hospital | Xi'an | Shannxi |
Lead Sponsor | Collaborator |
---|---|
Xijing Hospital |
China,
Ramos-Gonzalez G, Salazar L, Wittig O, Diaz-Solano D, Cardier JE. The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing. Arch Dermatol Res. 2023 May;315(4):815-823. doi: 10.1007/s00403-022-02451-y. Epub 2022 Nov 3. — View Citation
Zhang Y, Xing F, Luo R, Duan X. Platelet-Rich Plasma for Bone Fracture Treatment: A Systematic Review of Current Evidence in Preclinical and Clinical Studies. Front Med (Lausanne). 2021 Aug 3;8:676033. doi: 10.3389/fmed.2021.676033. eCollection 2021. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | X-ray | The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes. | pre-operation,3 weeks after treatment, 6 months after treatment | |
Primary | CT | The application of three-dimensional CT scan for the assessment of articular cartilage defects. | pre-operation,3 weeks after treatment, 6 months after treatment | |
Primary | MRI | The injury of ligaments, meniscus, and the knee joint was assessed using MRI. | pre-operation,3 weeks after treatment, 6 months after treatment |
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