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Cartilage Degeneration clinical trials

View clinical trials related to Cartilage Degeneration.

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NCT ID: NCT06368544 Recruiting - Clinical trials for Anterior Cruciate Ligament Injuries

Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction

Start date: January 7, 2024
Phase: N/A
Study type: Interventional

A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical characteristics of cartilage and the biomechanical risk index were proposed to providing exercise guidance and training for middle-aged people and it is suggested that it can prevent and reduce the risk of cartilage degeneration early after operation.

NCT ID: NCT06249906 Recruiting - Clinical trials for Osteo Arthritis Knee

Efficacy of Bioceramic Materials for Bone Defects Repair

Start date: February 20, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to demonstrate the effect of bioceramic implants on the repair of human bone defects, and to explore the application of bioceramic materials in bone defects, bone implantation, and bone fusion. The surface microstructure of β-tricalcium phosphate bioceramic implants can be effectively controlled to guide the regeneration of bones, promote the restoration of bones, accelerate the speed of recovery, and improve bone quality, which is of great clinical and social significance.

NCT ID: NCT05999266 Completed - Clinical trials for Rheumatoid Arthritis

The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis

Start date: September 28, 2023
Phase:
Study type: Observational [Patient Registry]

The knee pain status of the patients who are followed in the rheumatology special branch of the Physical Medicine and Rehabilitation Outpatient Clinic and who meet the inclusion criteria will be questioned. In patients with or without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest. The physician who performed the ultrasonographic measurements of the knee pain status of the patients does not know.

NCT ID: NCT05865899 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Impact of High Tibial Osteotomy in Preventing Degenerative Disease Progression in Medial Knee Osteoarthritis.

HTO-IOR
Start date: May 17, 2021
Phase: N/A
Study type: Interventional

High tibial osteotomy (HTO) surgical procedure can lead to clinically significant improvements in the cartilage and in subchondral bone quality, with a slow down of the osteoarthritis (OA) progression. Aim of the project is to: (i) clinically validate a 3D planned HTO surgical approach, through a quantitative grading of OA progression in a prospective randomized case-control clinical trial; (ii) correlate the internal knee loads with the changes assessed in cartilage and subchondral bone status to verify the hypothesis that HTO induced mechanical changes are associated with clinically significant OA improvements; (iii) relate imaging data with cartilage and subchondral bone mechanical properties, in order to classify OA progression in a more sensitive manner and allow a more precise diagnosis of the pathology stage.

NCT ID: NCT04968665 Not yet recruiting - Clinical trials for Anterior Cruciate Ligament Injuries

The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

Start date: August 1, 2021
Phase:
Study type: Observational

Explore The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

NCT ID: NCT04536103 Recruiting - Osteoarthritis Clinical Trials

Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

MVMS_MRI
Start date: April 1, 2022
Phase:
Study type: Observational

Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.

NCT ID: NCT04486534 Completed - Clinical trials for Cartilage Degeneration

The Assessment of Talar Cartilage in Patients With Unilateral Traumatic Transtibial Amputation

Start date: July 26, 2020
Phase:
Study type: Observational

Increased risk of osteoarthritis (OA) has been previously demonstrated in patients with lower limb amputation. Although there are many studies on knee joint of intact limb of amputees in the literature, the number of studies on intact foot and ankle is extremely limited. The primary aim of the study is to compare the intact talar cartilage, tibialis anterior and gastrocnemius muscle thickness measurements of traumatic unilateral transtibial amputee patients with that of healthy individuals using ultrasound. The secondary aim is to investigate the relationship between cartilage and muscle thickness measurements with clinical parameters.

NCT ID: NCT04454164 Completed - Knee Osteoarthritis Clinical Trials

Platelet Rich Plasma Injection for Knee Osteoarthritis

Start date: June 1, 2018
Phase: Early Phase 1
Study type: Interventional

The research questions of this study are; 1. Is platelet rich plasma (PRP) treatment effective in knee osteoarthritis (OA)? 2. What are the indications for PRP treatment? 3. Which patients are the most suitable for the PRP treatment method? 4. How does age, Body Mass Index (BMI), lower extremity mechanical axis angle and OA stages affect the success of the PRP treatment? 5. Is there any advantage of multiple PRP doses? 6. What is the therapeutic effect of placebo? This study was designed to find answers of these questions. The hypotheses of this study are; "PRP treatment is more effective than placebo; PRP treatment effectiveness decreases with age and advanced stages of OA; BMI is a factor that negatively affects the treatment effectiveness of the PRP; as the mechanical axis angle of the lower limb increases, it will adversely affect the effectiveness of PRP therapy; multiple dose of PRP affects the effectiveness and duration of PRP as positively compared to single dose of PRP". The primary purpose of this study; to prove the effectiveness of PRP treatment on knee pain and functions in patients with knee OA by comparing it with the placebo control group. Secondary purposes of this study; to understand the effect of age, BMI, OA grade and lower limb mechanical axis angle on PRP effectiveness. This study, designed as a randomized, double-blind and placebo control group, with a high level of scientific evidence. Thus, it will be scientifically possible to find answers to the investigators research questions and to prove the investigators hypothesis.

NCT ID: NCT04310852 Recruiting - Knee Osteoarthritis Clinical Trials

Knee Osteoarthritis Treatment With Percutaneous Injections of Autologous Bone Marrow Concentrate

Bone-Gun
Start date: June 6, 2018
Phase:
Study type: Observational

Recently there has been a growing interest in the role of subchondral bone in knee arthritis, both in its etiology and evolution and in its clinical significance. It has now been widely demonstrated that changes in the subchondral bone can develop both as a cause and as a consequence of joint degeneration and it is now accepted in the scientific community that the presence of these changes is of clinical importance, causing pain and an inflammatory state that can contribute to the evolution of arthrosis arthropathy. Recently the use of mesenchymal cells obtained from the bone marrow has been proposed for the treatment of gonarthrosis by intra-articular injections. Even more recently, treatments have been studied and proposed for the treatment of the bone-cartilage interface in knees affected by osteoarthrosis, using autologous bone marrow concentrate, with promising results.

NCT ID: NCT03955497 Recruiting - Knee Osteoarthritis Clinical Trials

Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury

Start date: October 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee. Investigator believe that this method will enable patients to recover better knee function and more repair of knee cartilage.