Carotid Stenosis Clinical Trial
Official title:
Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Carotid Endarterectomy and Cerebral Aneurysmectomy.
The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the CEA and Cerebral Aneurysmectomy about antioxidant effect.
CEA and Cerebral Aneurysmectomy may lead to regional ischemic reperfusion injury.
Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in
rats.
As for sevoflurane, some investigation indicated that sevoflurane is able to reduce
oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant
effect did not found in human minor incision surgeries, furthermore, oxidative stress was
raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy,
and thoracotomy
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
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