Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting

Carotid Stenosis Clinical Trial

Official title: Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting

Status Completed

Clinical Trial Summary

New brain ischemic lesions are detected in about 50% of patients undergoing carotid artery stenting (CAS). The aim was to assess correlation between selected laboratory markers and occurrence of new brain infarctions after CAS.

Clinical Trial Description

Methods: All consecutive patients 1) with internal carotid artery stenosis >70%, 2) indicated to CAS, 3) with signed informed consent were enrolled to the prospective study during 16 months. All patients used dual antiplatelet therapy (acetylsalicylic acid [ASA] 100 mg + clopidogrel 75 mg per day) at least 7 days before CAS. Neurological examination and brain magnetic resonance imaging (MRI) were performed before and 24 hours after CAS in all patients. Venous blood samples were collected within 24 hours before CAS in all patients: hematology + reticulocytes, coagulation markers (PT, APTT, INR, Fbg, Clauss), vWF antigen, PAI-1 activity, PAI-1 polymorphism 4G/g, Multiplate (ASA and clopidogrel resistance test). Blood samples for the assessment of anti Xa activity were collected during CAS. T-test was used for statistical evaluation. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Brain Ischemia
• Carotid Stenosis
• Laboratory Problem

• NCT number: NCT02310191
• Study type: Observational
• Source: University Hospital Ostrava
• Status: Completed
• Phase: N/A
• Start date: July 2012
• Completion date: November 2014