Cardiovascular Disease Clinical Trial
Official title:
NOR-SYS: The Norwegian Stroke in the Young Study Young Ischemic Stroke and Family Risk Factors
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60
years. Patients, partners and the couple´s adult children who are at least 18 years old, are
all invited to ultrasound examinations due to a standardized protocol.
Parents of patients and partners are invited to return their answers of standardized
questionnaires about clinical ischemic events such as stroke, angina or myocardial infarction
or peripheral artery disease.
Study inclusion time of patients and their families is 5 years. A biobank is build from
samples from patients, partners and adult children. Clinical follow-ups for patients and
partners are planned after 5, 10 and 15 years. Clinical follow-ups for adult children are
planned after 10 and 20 years.
Hypotheses:
What do patients know about their parents clinical ischemic events? How much established
pathology in arteries do we find by a standardized ultrasound protocol at the time of
ischemic stroke at a young age? Differences concerning risk factors and ultrasound findings
between patients and partners? Differences between children from families with several
ischemic events among parents and grandparents vs. children from families without ischemic
events? Biochemical markers related to ultrasound findings and artery disease.
Equal examinations for patients, partners and adult children are:
- Standardized questionnaires
- Extracranial duplexsonography
- Duplexsonography of the abdominal aorta
- Duplexsonography of femoral arteries
- Duplexsonography of epicardial, intrabdominal and subcutaneous fat
- Peripheral ultrasound, Ankle-arm index
- ECG
- Blood pressure measurement
- BMI and Waist-hip ratio
- Blood samples
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