Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients

Caries, Dental Clinical Trial

Official title:

Evaluation the Efficacy of a Herbal Licorice on Reducing Salivary Streptococcus Mutans Levels (A Randomized Clinical Trial)

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03590977
• Other study ID #: CEBD-CU-2018-07-5
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 1, 2018
• Est. completion date: October 1, 2019

Study information

• Verified date: July 2018
• Source: Cairo University
• Contact: nancy helmy, Msc
• Phone: 01002715841
• Email: nancy.helmy[@]dentistry.cu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.

Description:

A total number of fifty-two patients will be enrolled in the study. They will be divided into two groups: study group and control group. Study group will be subjected to licorice mouthwash and the control will be subjected to chlorohexidine mouth wash. Salivary bacterial count will be evaluated for both groups.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 52
• Est. completion date: October 1, 2019
• Est. primary completion date: August 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• over 18 years old

• co-operative patients

• not allergic to licorice

• not allergic to chlorohexidine

Exclusion Criteria:

• pregnancy

• allergic patients to licorice

• allergic patients to chlorohexidine

• lack of compliance

• evidence of parafunctional habits

• patients with periodontal disease

• xerostomia

• participants that receive any microbial agent two weeks prior to the study

Related Conditions & MeSH terms

• Caries, Dental
• Dental Caries

Intervention

Other:
• licorice extract mouthwash
mouth rinse that contains a natural herbal licorice root extract used as a preventive measure that reduce caries index.
• chlorohexidine mouthwash
mouth wash that contains chlorohexidine as an active component

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

References & Publications (2)

Almaz ME, Sönmez IS, Ökte Z, Oba AA. Efficacy of a sugar-free herbal lollipop for reducing salivary Streptococcus mutans levels: a randomized controlled trial. Clin Oral Investig. 2017 Apr;21(3):839-845. doi: 10.1007/s00784-016-1827-y. Epub 2016 Apr 30. — View Citation

Jain E, Pandey RK, Khanna R. Liquorice root extracts as potent cariostatic agents in pediatric practice. J Indian Soc Pedod Prev Dent. 2013 Jul-Sep;31(3):146-52. doi: 10.4103/0970-4388.117964. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	salivary bacterial count	streotococcus mutans bacterial count	after one week