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Caries, Dental clinical trials

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NCT ID: NCT06317857 Not yet recruiting - Caries, Dental Clinical Trials

Clinical Performance of an Alkasite-based Restorative Material

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The evolution of restorative dental materials and technology has enabled the use of tooth-colored restorative materials in dental restorations, with all dentists hoping for the presence of materials that combine biocompatible qualities and aesthetics . Although resin composite materials' mechanical and aesthetic properties have greatly improved over the past 20 years, research is currently on to find ways to prevent secondary caries from forming beneath and at the margins of restorations. In order to circumvent these problems, there is a growing tendency towards the use of resin-based bioactive and remineralizing restorative materials to strengthen and lengthen the lifespan of bonded dental restorations.

NCT ID: NCT06308796 Recruiting - Clinical trials for Head and Neck Cancer

Prevention of Caries in Head and Neck Cancer Survivors Who Underwent Radiotherapy

RADIOCARIES
Start date: April 1, 2023
Phase: N/A
Study type: Interventional

One of the long-term side effects of head and neck radiotherapy (RT) is radiation-induced tooth decay. Hyposalivation, associated with radiation therapy, further increases caries susceptibility and caries progression, due to the lack of salivary protective effects and of tooth minerals useful for remineralization processes, especially calcium phosphate (CaP). Dental extractions that could be required in case of severe tooth decay expose the patient to the risk of osteoradionecrosis of the jaws (i.e. the necrosis of the bone tissue following a local trauma, including surgical trauma). This protocol aims at verifying the effectiveness of CaP mousse in the prevention of carious lesions, added to topical fluoride. A randomized controlled clinical trial will be performed comparing CaP + fluoride treatment versus no treatment in head and neck cancer patients, who received radiotherapy. The hypothesis is that CaP, which is lacking in the mouth of these patients due to hyposalivation, can combine with fluoride to promote remineralization, reducing the risk of carious lesions.

NCT ID: NCT06242184 Completed - Caries,Dental Clinical Trials

Post-operative Sensitivity in Resin Composites

Start date: May 15, 2023
Phase: N/A
Study type: Interventional

This triple-blind, randomized clinical trial was conducted at the department of Operative dentistry. A total of 60 participants were recruited and were randomly distributed into two groups A and B. After informed consent, restorative treatment was performed. In group A, adhesive with nanoparticles was used for composite restoration while in group B, adhesive without nanoparticles was utilized. Post-operative sensitivity was recorded using VAS score.

NCT ID: NCT06231823 Recruiting - Caries Clinical Trials

Extraction of the Compromised First Permanent Molars

FPM
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

Compromised first permanent molars (FPM), whether diagnosed with severe molar incisor hypomineralization (MIH), irreversible pulpities, or necrosis, require frequent re-treatment consequently entering the restorative cycle, which leads to their inevitable extraction and implant placement. Extraction of compromised first permanent molars in 8-10-year-old children allows the mesial migration of the second permanent molars during their eruption, thereby favoring spontaneous space closure as a permanent solution.

NCT ID: NCT06211582 Active, not recruiting - Caries,Dental Clinical Trials

Clinical Performances of 3-different Tooth-colored Restorative Materials in Class-II Cavities

Start date: September 15, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial comparatively investigate the clinical performances of 3 different tooth-colored restorative materials in the treatment of Class II cavities after 6 months and one year.

NCT ID: NCT06192667 Active, not recruiting - Caries,Dental Clinical Trials

Clinical Performance of Injectable Composite Resins in Class I Cavities

Start date: December 12, 2022
Phase: N/A
Study type: Interventional

Purpose of research: Evaluation and comparison of 24-month clinical performance of injectable and conventional resin composites in class I cavities.

NCT ID: NCT06182267 Completed - Caries,Dental Clinical Trials

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

Start date: November 27, 2023
Phase: Phase 1
Study type: Interventional

Pharmacokinetic (PK) study of L-arginine after exaggerated oral use of the novel dentifrice product COL101 after repeated daily applications in healthy adult subjects.

NCT ID: NCT06162182 Active, not recruiting - Caries,Dental Clinical Trials

Comparative Evaluation of an Electrical Impedance Device Versus Digital Radiography in Estimation of Remaining Dentin Thickness

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

The research question was that in patients with carious posterior permanent teeth, would the electrical impedance device be as valid as digital radiography in estimation of remaining dentin thickness? The proposed hypothesis was null.

NCT ID: NCT06152081 Recruiting - Caries,Dental Clinical Trials

Caries Detection With Two Different Caries Detecting Devices

Start date: April 2024
Phase: N/A
Study type: Interventional

The primary aim of this study will be to compare the effectiveness of the novel LumiCareā„¢ rinse and with QLF in determining caries progression. The secondary aim is to compare the progression of carious lesions between patients who reported use of e-cigarettes/vapes and those who did not.

NCT ID: NCT06114030 Recruiting - Caries,Dental Clinical Trials

Clinical and Radiographical Evaluation of CAD-CAM Crowns With and Without Deep Margin Elevation

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

Deep margin elevation (DME) is a non-invasive restorative technique to relocate the deep cervical margin to a supragingival position using resin composite. This retrospective multicenter practice-based study will assess the long-term clinical performance and periodontal health of teeth restored with CAD-CAM crowns with or without DME. Patients who will receive CAD-CAM lithium disilicate (LD) crowns with or without DME between 2013 and 2023 at multiple private practices will be included. When indicated, DME will be performed using resin-based restoration. Clinical assessment of the crowns and supporting periodontal structures will be performed following the modified United States Public Health Service (USPHS) criteria. Intra-oral photographs, periapical and bitewing radiographs will be taken for further assessment by three evaluators. Kaplan Meier survival analyses will be performed.