Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

Cardiovascular Clinical Trial

Official title:

Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04121416
• Other study ID #: Oxycodone VS Sufentanil
• Status: Completed
• Phase: N/A
• Start date: April 1, 2019
• Est. completion date: September 19, 2019

Study information

• Verified date: April 2019
• Source: Shengjing Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

Description:

Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR [1.2]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: September 19, 2019
• Est. primary completion date: August 31, 2019
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 60 Years to 85 Years

Eligibility

Inclusion Criteria:

The coronary angiography from each patient showed that lesions exist in at least one main coronary artery

Exclusion Criteria:

a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway

Related Conditions & MeSH terms

• Cardiovascular
• Coronary Artery Disease
• Coronary Disease
• Heart Diseases
• Myocardial Ischemia

Intervention

Drug:
• Oxycodone 10mg
induction with 0.3mg/kg of oxycodone in general anesthesia
• Sufentanil
induction with 0.3 µg/kg of Sufentanil in general anesthesia

Locations

Country	Name	City	State
China	shengjing hospital of China medical university	Shenyang	Liao Ning

Sponsors (1)

Lead Sponsor	Collaborator
Shengjing Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	blood pressure(SBP)?diastolic blood pressure(DBP)?mean arterial pressure(MAP)	Under local anesthesia invasive artery line was put to the patients to monitor systolic blood pressure(SBP)?diastolic blood pressure(DBP)?mean arterial pressure(MAP)	one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation