Cardiovascular Diseases Clinical Trial
— LPACOOfficial title:
Investigating The Prevalence and Clinical Significance of Elevated Lipoprotein(a) Blood Levels in Hospital Staff
The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population.
| Status | Not yet recruiting |
| Enrollment | 2800 |
| Est. completion date | December 31, 2036 |
| Est. primary completion date | December 1, 2035 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 21 Years to 100 Years |
| Eligibility | Inclusion Criteria: Any hospital staff aged 21 and above. Family members of index cases of high elevated lipoprotein(a) can also participate in this study Exclusion Criteria: - Inability to provide informed consent |
| Country | Name | City | State |
|---|---|---|---|
| Singapore | Clinical Trials & Research Unit | Singapore |
| Lead Sponsor | Collaborator |
|---|---|
| Changi General Hospital |
Singapore,
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgozoglu LS, Catapano AL. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. Eur Heart J. 2022 Oct 14;43(39):3925-3946. doi: 10.1093/eurheartj/ehac361. — View Citation
Loh WJ, Chan DC, Mata P, Watts GF. Familial Hypercholesterolemia and Elevated Lipoprotein(a): Cascade Testing and Other Implications for Contextual Models of Care. Front Genet. 2022 Apr 27;13:905941. doi: 10.3389/fgene.2022.905941. eCollection 2022. — View Citation
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK. Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population. Atherosclerosis. 2022 May;349:160-165. doi: 10.1016/j.atherosclerosis.2021.11.018. Epub 2021 Nov 26. — View Citation
Loh WJ, Watts GF. Detection strategies for elevated lipoprotein(a): will implementation let the genie out of the bottle? Curr Opin Endocrinol Diabetes Obes. 2023 Apr 1;30(2):94-102. doi: 10.1097/MED.0000000000000789. Epub 2022 Dec 5. — View Citation
Nestel P, Loh WJ, Ward NC, Watts GF. New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease. J Clin Endocrinol Metab. 2022 Nov 23;107(11):e4281-e4294. doi: 10.1210/clinem/dgac541. Erratum In: J Clin Endocrinol Metab. 2022 Oct 20;: — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Distribution and prevalence of elevated Lipoprotein(a) | Investigate the distribution lipoprotein(a) and prevalence of elevated lipoprotein(a) concentrations in various ethnicities. | 3 years | |
| Secondary | Correlation of lipoprotein(a) with cardiovascular outcomes | Observational study to assess the correlation of degree of elevation of lipoprotein(a) with cardiovascular outcomes prospectively. | 10 years | |
| Secondary | Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events | Assess the association of genetic variants of lipoprotein(a) with the measured lipoprotein(a) concentrations in various ethnicities, and prospectively assess the association of these genetic variants with cardiovascular outcomes | 10 years |
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