Zhejiang Nutrition and Health Study

Cardiovascular Diseases Clinical Trial

— NuLife  

Official title:

Zhejiang Nutrition and Health Study: Nutrition and Lifespan Study (NuLife Study)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05930717
• Other study ID #: 20230511JZS001
• Status: Recruiting
• Start date: July 19, 2023
• Est. completion date: July 2033

Study information

• Verified date: August 2023
• Source: Westlake University
• Contact: Wanglong Gou, PhD
• Phone: 86-13819107649
• Email: gouwanglong[@]westlake.edu.cn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups. The demographic, diet, lifestyle information, health status, and corresponding bio-samples will be collected carefully. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to evidence-based nutrition interventions to improve health outcomes and enhance quality of life.

Description:

This project aims to elucidate the relationship between healthy lifespan and nutrition through the establishment of a large-scale cohort of participants and longitudinal follow-ups spanning around 10 years in Zhejiang Province. The cohort will comprise individuals in a wide range of age groups starting at 6 years old. The participants will provide demographic information, anthropometry measurements, detailed diet, lifestyle data and health status, including 3-day dietary records and long-term food intake frequency recalls. Integrated with previous information, diverse bio-samples will also be collected to establish a multi-dimensional biobank. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to the development of evidence-based nutrition designed to improve health outcomes and enhance the quality of life for individuals of all ages.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10000
• Est. completion date: July 2033
• Est. primary completion date: July 2033
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Years and older

Eligibility

Inclusion Criteria:

• Chinese citizens who have resided in the surveyed area for at least 6 months before the survey within the last 12 months.
• Aged 6 years or older.
• They are included as resident households, which are comprised of people living together in one place based on family relationships, and at least one resident with permanent household registration.

Exclusion Criteria:

• Residents living in functional zones such as construction worker dormitories, military barracks, schools, nursing homes, etc.

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Healthy Aging
• Metabolic Disease
• Metabolic Diseases

Locations

Country	Name	City	State
China	Westlake University	Hangzhou	Zhejiang
China	Zhejiang Provincial Center for Disease Control and Prevention	Hangzhou	Zhejiang

Sponsors (2)

Lead Sponsor	Collaborator
Westlake University	Zhejiang Provincial Center for Disease Control and Prevention

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Occurrence of cardio-metabolic diseases	The investigators will track for occurrence of cardio-metabolic diseases by follow-up surveys collected by the Zhejiang Center for Disease Control and Prevention.	up to 10 years
Secondary	Changes in fasting blood glucose	Fasting glucose will be examined in mmol/L.	Every other year, up to 10 years
Secondary	Changes in fasting blood HbA1c	Fasting blood HbA1c will be examined in %	Every other year, up to 10 years
Secondary	Changes in fasting lipid metabolism	Triglyceride, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol will be examined in mmol/L.	Every other year, up to 10 years
Secondary	Changes in fasting blood highly sensitive C-reactive protein (CRP)	CRP will be examined in mg/L.	Every other year, up to 10 years
Secondary	Changes in body mass index	Body mass index (BMI) will be calculated in kg/m^2	Every other year, up to 10 years
Secondary	Changes in blood pressure	Blood pressure, including systolic and diastolic blood pressure, will be measured in mmHg	Every other year, up to 10 years
Secondary	Changes in gut microbiome profiling	16S rRNA and/or shotgun metagenomic sequencing will be performed in stool samples.	Every other year, up to 10 years