FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN

Status Recruiting

Clinical Trial Summary

The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.

Clinical Trial Description

The main objective of the STANISLAS cohort is to identify the factors associated with cardiovascular aging (assessed through the study of the degradation of morphological and functional parameters of the heart and vascular systems). Data (clinical, biological, morphological, genetic and lifestyle) from previous visits (the first having been initiated in the mid-1990s) will be considered as exposure and / or adjustment variables. The exposure variables of interest will be: - The components of metabolic syndrome (MS), - Genetic determinants, through an approach of family segregation and candidate genes, - Multi-omic biomarkers analyzed from the biological collection of the first assessments of the cohort - Food intake, nutrition and eating behavior The secondary objectives are - Identify the factors associated with a degradation of renal parameters (renal function and proteinuria). - Identify the factors associated with a degradation of metabolic parameters. - To assess the association between SARS-CoV-2 infection (questionnaire and serological approach) and cardiovascular and renal parameters - Identify factors associated with the occurrence of clinical cardiovascular events. - Association between Covid 19 events and general disabling symptoms - Complete the cohort's biological collection for future biomarker assays related to previous objectives ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05916287
Study type	Interventional
Source	Central Hospital, Nancy, France
Contact
Status	Recruiting
Phase	N/A
Start date	July 13, 2023
Completion date	July 13, 2027

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms