The STandard Versus ImAging SuBstrate Aided Ablation in Severe Left VEntricular Dysfunction VT. — STABLE-VT  

Cardiovascular Diseases Clinical Trial

Official title: The STandard Versus ImAging SuBstrate Aided Ablation in Severe Left VEntricular

Status Recruiting

Clinical Trial Summary

The STABLE-VT trial aims to determine the safety profile and clinical efficacy of a modified approach to ventricular tachycardia (VT) ablation that integrates myocardial scar as visualized on cardiac magnetic resonance (c-MRI) or CT into electroanatomical mapping (EAM) for VT ablation.

Clinical Trial Description

The STABLE-VT trial aims to integrate myocardial scar as visualized on cardiac magnetic resonance (c-MRI) or CT into electroanatomical mapping (EAM) for VT ablation. Particularly, we will compare the procedural safety, and acute and long-term clinical efficacy of this imaging-aided VT ablation protocol to standard of care.

Our hypothesis is that patients with ventricular tachycardia (VT) and severe LV dysfunction randomized to this imaging-aided protocol will have shorter procedure duration, improved procedural hemodynamic stability, fewer acute major adverse cardiovascular events (MACE), less need for mechanical support, comparable freedom from VT at noninvasive programmed stimulation (NIPS) sub-acutely after the procedure, and at two-year follow-up compared to standard ablation approach. Herein, our outcomes of interest will be captured during the two years following as part of regular standard of care follow-ups. ;

Related Conditions & MeSH terms

• Cardiovascular Diseases

• NCT number: NCT05828667
• Study type: Interventional
• Source: University of Pennsylvania
• Contact: Godefroy S Chery
• Phone: 6052515666
• Email: godefroy.chery@pennmedicine.upenn.edu
• Status: Recruiting
• Phase: N/A
• Start date: October 1, 2023
• Completion date: March 1, 2026