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NCT05600010 Clinical Trial

Detection of Microplastics in Cardiac Surgery Patients

Cardiovascular Diseases Clinical Trial

Official title:
Detection of Microplastics in Cardiac Surgery Patients: Its Metabolic Pathways and Toxic Effects

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05600010
Other study ID # default
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date November 1, 2022
Est. completion date October 22, 2023

Study information
Verified date October 2022
Source Beijing Anzhen Hospital
Contact Kun Hua, M.D.
Phone +8615810111206
Email huakun0310@126.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The exponential growth in plastic production/use translates into a parallel increase in environmental plastic waste, which is constantly degraded into microplastics and nanoplastics. Information on the effects of microplastics on human health is still preliminary. Cardiac surgery patients is a population high exposed to plastics. This observational study will obtain biological samples of cardiac surgery patients as a reference and vulnerable group of individuals highly exposed to microplastics and potentially more susceptible. The objective of this research is to be able to detect microplastics on blood and operation samples of cardiac surgery patients as well as their potential genotoxic and immunological damage.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 40
Est. completion date October 22, 2023
Est. primary completion date May 31, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Age =18 years - Elective cardiac surgery Exclusion Criteria: - Emergency surgery or limited-term surgery - Previous cardiac surgery - Previous severe liver disease - Pregnant or planning to become pregnant - Have a malignant tumor

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Microplastics
Detection of microplastics as a yes/no value

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Kun Hua

Outcome
Type Measure Description Time frame Safety issue
Primary Detection of microplastics in human heart tissue and the blood Detection of microplastics in human heart tissue and the blood undergoing cardiac surgery perioperative: preoperative and pro-/postoperative blood and intraoperative heart tissue
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