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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05435898
Other study ID # NSS_2
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date October 1, 2022
Est. completion date September 30, 2029

Study information

Verified date June 2022
Source Shanghai 10th People's Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To comprehensively evaluate subclinical organ damage of Chinese adults and its association with future cardiovascular disease and events. To observe the significance of intervention based on digital health in preventing the onset and/or progression of subclinical organ damage and cardiovascular disease and events.


Description:

In this project, we will register outpatients with cardiovascular diseases and healthy subjects for cardiovascular health check-up in the cardiovascular research clinic of our hospital, comprehensively evaluate their cardiovascular risk factors, subclinical organ damage and cardiovascular diseases at baseline. For participants who is willing to go further, a digital-based intervention will be provided for them to improve their knowledge and behaviour on cardiovascular health. For all participants, their status on subclinical organ damage, cardiovascular diseases and events will be followed within five years. The primary outcome is the composite endpoints of cardiovascular adverse events including acute coronary syndrome, myocardial infarction, heart failure, cardiovascular death. The secondary outcomes include individual cardiovascular adverse events, all-cause mortality, subclinical organ damage including cardiac damage (left ventricular hypertrophy and diastolic dysfunction), renal damage (chronic kidney disease, microalbuminuria), and vascular damage (arterial stiffness, plaques, intima-median thickening, retina arteriosclerosis). By doing these, we will be able to build a registry study and to reveal the epidemiology of subclinical organ damage, validate the association between subclinical organ damage and cardiovascular events in Chinese, and explore the significance of digital-based intervention in the prevention from subclinical organ damage and cardiovascular diseases and events.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 4000
Est. completion date September 30, 2029
Est. primary completion date September 30, 2029
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - aged 18 years or older - willing to participate the study and sign informed consent - available for long-term follow-up Exclusion Criteria: - severe heart disease (NYHA IV) - stage 4 or 5 CKD - malignant tumors or with life expectancy less than 5 years - stroke within 3 months - refuse to participate the study or not available for long-term follow up

Study Design


Locations

Country Name City State
China Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai Shanghai

Sponsors (1)

Lead Sponsor Collaborator
Shanghai 10th People's Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary composite endpoint of cardiovascular events rate of subject with myocardial infarction, stroke, heart failure, cardiovascular death 5 years
Secondary Individual cardiovascular events rate of subject with individual components of composite endpoint 5 years
Secondary all cause mortality rate of death 5 years
Secondary New on-set subclinical organ damage Rate of subject with new on-set subclinical organ damage. Subclinical organ damage evaluated contains heart (left ventricular hypertrophy and diastolic dysfunction), kidneys (chronic kidney disease, microalbuminuria), vasculature (arterial stiffness, carotid plaque, intima-media thickness), and eye background (arteriosclerotic retinopathy). 5 years
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